Secondary metabolism in cannabis

IJ Flores-Sanchez, R Verpoorte - Phytochemistry reviews, 2008 - Springer
Cannabis sativa L. is an annual dioecious plant from Central Asia. Cannabinoids,
flavonoids, stilbenoids, terpenoids, alkaloids and lignans are some of the secondary …

The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia

JC Fruchart, F Sacks, MP Hermans, G Assmann… - The American journal of …, 2008 - Elsevier
Despite achieving targets for low-density lipoprotein (LDL) cholesterol, blood pressure, and
glycemia in accordance with current standards of care, patients with dyslipidemia remain at …

Cytotoxic edema: mechanisms of pathological cell swelling

D Liang, S Bhatta, V Gerzanich, JM Simard - Neurosurgical focus, 2007 - thejns.org
✓ Cerebral edema is caused by a variety of pathological conditions that affect the brain. It is
associated with two separate pathophysiological processes with distinct molecular and …

Treatment modalities of obesity: what fits whom?

V Hainer, H Toplak, A Mitrakou - Diabetes care, 2008 - Am Diabetes Assoc
The prevalence of obesity is increasing in both developed and developing countries, with
rates reaching∼ 10–35% among adults in the Euro-American region. Obesity is associated …

Aryl radical activation of C–O bonds: copper-catalyzed deoxygenative difluoromethylation of alcohols

A Cai, W Yan, W Liu - Journal of the American Chemical Society, 2021 - ACS Publications
Given their ubiquity in natural products and pharmaceuticals, alcohols represent one of the
most attractive starting materials for the construction of C–C bonds. We report herein the first …

The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patients

JC Fruchart, FM Sacks, MP Hermans… - Diabetes and …, 2008 - journals.sagepub.com
Despite current standards of care aimed at achieving targets for low-density lipoprotein
(LDL) cholesterol, blood pressure and glycaemia, dyslipidaemic patients remain at high …

In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs

RA Thompson, EM Isin, Y Li, L Weidolf… - Chemical research in …, 2012 - ACS Publications
Idiosyncratic adverse drug reactions (IADRs) in humans can result in a broad range of
clinically significant toxicities leading to attrition during drug development as well as …

Effect of obesity on high‐density lipoprotein metabolism

S Rashid, J Genest - Obesity, 2007 - Wiley Online Library
Reduced levels of high‐density lipoproteins (HDL) in non‐obese and obese states are
associated with increased risk for the development of coronary artery disease. Therefore, it …

Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis

DR Janero, A Makriyannis - Expert opinion on emerging drugs, 2009 - Taylor & Francis
The endogenous cannabinoid (CB)(endocannabinoid) signaling system is involved in a
variety of (patho) physiological processes, primarily by virtue of natural, arachidonic acid …

Diabesity: therapeutic options

S Colagiuri - Diabetes, obesity and metabolism, 2010 - Wiley Online Library
A pathogenic relationship exists between type 2 diabetes and obesity. Over the last decade,
the escalation in diabetes cases has paralleled the rapid increase in obesity rates …