• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

In this scientific statement from the American Heart Association, experts in the field of
cardiomyopathy (heart muscle disease) in children address 2 issues: the most current …

Single-cell RNA sequencing is a powerful tool to study developmental biology but does not
preserve spatial information about tissue morphology and cellular interactions. Here, we …

Excessive trabeculation, often referred to as “noncompacted” myocardium, has been
described at all ages, from the fetus to the adult. Current evidence for myocardial …

The evidence is increasing that left ventricular noncompaction cardiomyopathy as it is
currently defined does not represent a failure of compaction of pre-existing trabecular …

New coronary vessels are added to the heart around birth to support postnatal cardiac
growth. Here we show that, in late fetal development, the embryonic coronary plexus at the …

Background Left ventricular (LV) hypertrabeculation fulfilling noncompaction
cardiomyopathy criteria has been detected in athletes. However, the association between …

Noncompaction cardiomyopathy (NCCM) has gained increasing attention over the past
twenty years, but in daily clinical practice NCCM is still rarely considered. So far, there are …

Left ventricular non-compaction (LVNC) describes the phenotypical phenomena
characterized by the presence of excessive trabeculation of the left ventricle which forms a …

Heart development is topographically complex and requires visualization to understand its
progression. No comprehensive 3-dimensional primer of human cardiac development is …