Detecting biothreat agents: From current diagnostics to developing sensor technologies

SA Walper, G Lasarte Aragonés, KE Sapsford… - ACS …, 2018 - ACS Publications
Although a fundamental understanding of the pathogenicity of most biothreat agents has
been elucidated and available treatments have increased substantially over the past …

Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development

N Zhao, Y Song, X Xie, Z Zhu, C Duan… - … and Targeted Therapy, 2023 - nature.com
The fast-developing synthetic biology (SB) has provided many genetic tools to reprogram
and engineer cells for improved performance, novel functions, and diverse applications …

Phage-based applications in synthetic biology

S Lemire, KM Yehl, TK Lu - Annual review of virology, 2018 - annualreviews.org
Bacteriophage research has been instrumental to advancing many fields of biology, such as
genetics, molecular biology, and synthetic biology. Many phage-derived technologies have …

Engineered Reporter Phages for Rapid Bioluminescence-Based Detection and Differentiation of Viable Listeria Cells

S Meile, A Sarbach, J Du, M Schuppler… - Applied and …, 2020 - Am Soc Microbiol
The pathogen Listeria monocytogenes causes listeriosis, a severe foodborne disease
associated with high mortality. Rapid and sensitive methods are required for specific …

Approaches to optimize therapeutic bacteriophage and bacteriophage-derived products to combat bacterial infections

M Reuter, DH Kruger - Virus Genes, 2020 - Springer
The emerging occurrence of antibiotic-resistant bacterial pathogens leads to a recollection
of bacteriophage as antimicrobial therapeutics. This article presents a short overview of the …

Rapid detection of viable Acinetobacter baumannii and antibiotic susceptibility testing based on a phage amplification-Taqman qPCR assay

J Luo, X Zhang, M Liu, W Ai, X Zheng, S Liu, L Han… - Microchemical …, 2023 - Elsevier
Background Timely and accurate identification of pathogenic bacteria and antibiotic
susceptibility could decrease misuse and overuse of antibiotics. In this study, we developed …

Characterization of Mu-Like Yersinia Phages Exhibiting Temperature Dependent Infection

B Meng, Z Qi, X Li, H Peng, S Bi, X Wei, Y Li… - Microbiology …, 2023 - Am Soc Microbiol
Yersinia pestis is the etiological agent of plague. Marmota himalayana of the Qinghai-
Tibetan plateau is the primary host of flea-borne Y. pestis. This study is the report of isolation …

噬菌体合成生物学研究进展和应用

袁盛建, 马迎飞 - 合成生物学, 2020 - synbioj.cip.com.cn
噬菌体是地球上多样性最高和最丰富的生物体, 也是合成生物学研究中重要的模式生物.
噬菌体基因组相对较小, 结构简单, 是研究基本生命过程最简单的生物系统. 通过对噬菌体基因组 …

Genetically modified bacteriophages

AP Sagona, AM Grigonyte, PR MacDonald… - Integrative …, 2016 - academic.oup.com
Phages or bacteriophages, viruses that infect and replicate inside bacteria, are the most
abundant microorganisms on earth. The realization that antibiotic resistance poses a …

Rapid antimicrobial susceptibility testing of Bacillus anthracis, Yersinia pestis, and Burkholderia pseudomallei by use of laser light scattering technology

JV Bugrysheva, C Lascols, D Sue… - Journal of Clinical …, 2016 - Am Soc Microbiol
Rapid methods to determine antimicrobial susceptibility would assist in the timely
distribution of effective treatment or postexposure prophylaxis in the aftermath of the release …