Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

Late-stage functionalization (LSF) introduces functional group or structural modification at
the final stage of the synthesis of natural products, drugs, and complex compounds. It is …

Abstract Frustrated Lewis pairs (FLPs) are well documented for the activation of small
molecules such as dihydrogen and carbon dioxide,,–. Although canonical FLP chemistry is …

The ability to selectively introduce diverse functionality onto hydrocarbons is of substantial
value in the synthesis of both small molecules and polymers. Herein, we report an approach …

The progress of drug discovery and development is paced by milestones reached in organic
synthesis. In the last decade, the advent of late-stage functionalization (LSF) reactions has …

Abstract (Hetero) arenes continue to prove their indispensability in pharmaceuticals,
materials science, and synthetic chemistry. As such, the controllable modification of …

The oxidation of unactivated C–H bonds has emerged as an effective tactic in natural
product synthesis and has altered how chemists approach the synthesis of complex …

Skeletal editing involves making specific point‐changes to the core of a molecule through
the selective insertion, deletion or exchange of atoms. It thus represents a potentially …

Recognizing Nature's unique ability to perform challenging oxygenation reactions with
exquisite selectivity parameters at iron-dependent oxygenases, chemists have long sought …

Designing catalytic approaches to deliberate and selective C–H activation was listed by
Bergman among the “Holy Grails” of synthetic chemistry in 1995, and continues to be a hot …