Anti-tuberculosis treatment strategies and drug development: challenges and priorities

VA Dartois, EJ Rubin - Nature Reviews Microbiology, 2022 - nature.com
Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …

Antimicrobial resistance in ESKAPE pathogens

DMP De Oliveira, BM Forde, TJ Kidd… - Clinical microbiology …, 2020 - Am Soc Microbiol
Antimicrobial-resistant ESKAPE (E nterococcus faecium, S taphylococcus aureus, K
lebsiella pneumoniae, A cinetobacter baumannii, P seudomonas aeruginosa, and E …

Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N Xie, EC Nice, T Zhang… - Signal transduction and …, 2020 - nature.com
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Synergistic effects between metal nanoparticles and commercial antimicrobial agents: A review

AI Ribeiro, AM Dias, A Zille - ACS Applied Nano Materials, 2022 - ACS Publications
Nanotechnology has expanded into a broad range of clinical applications. In particular,
metal nanoparticles (MNPs) display unique antimicrobial properties, a fundamental function …

[HTML][HTML] Towards the sustainable discovery and development of new antibiotics

M Miethke, M Pieroni, T Weber, M Brönstrup… - Nature Reviews …, 2021 - nature.com
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

Infection microenvironment-related antibacterial nanotherapeutic strategies

Z Wang, X Liu, Y Duan, Y Huang - Biomaterials, 2022 - Elsevier
The emergence and spread of antibiotic resistance is one of the biggest challenges in public
health. There is an urgent need to discover novel agents against the occurrence of multidrug …

The physiology and genetics of bacterial responses to antibiotic combinations

R Roemhild, T Bollenbach, DI Andersson - Nature Reviews …, 2022 - nature.com
Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

[PDF][PDF] A dual-mechanism antibiotic kills gram-negative bacteria and avoids drug resistance

JK Martin, JP Sheehan, BP Bratton, GM Moore… - Cell, 2020 - cell.com
The rise of antibiotic resistance and declining discovery of new antibiotics has created a
global health crisis. Of particular concern, no new antibiotic classes have been approved for …

Caffeic acid and its derivatives: antimicrobial drugs toward microbial pathogens

F Khan, NI Bamunuarachchi… - Journal of agricultural …, 2021 - ACS Publications
Caffeic acid is a plant-derived compound that is classified as hydroxycinnamic acid which
contains both phenolic and acrylic functional groups. Caffeic acid has been greatly …

Two‐tailed dynamic covalent amphiphile combats bacterial biofilms

X Hu, Y Li, Y Piao, M Karimi, Y Wang, F Wen… - Advanced …, 2023 - Wiley Online Library
Drug combination provides an efficient pathway to combat drug resistance in bacteria and
bacterial biofilms. However, the facile methodology to construct the drug combinations and …