Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for
a wide variety of biological processes. We demonstrate that the N 6-adenosine …

Abstract Background Transcriptome sequencing (RNA-Seq) has become the assay of
choice for high-throughput studies of gene expression. However, as is the case with …

The unfolded protein response (UPR) regulates gene expression in response to stress in the
endoplasmic reticulum (ER). We determined the transcriptional scope of the UPR using DNA …

We used genome-wide expression analysis to explore how gene expression in
Saccharomyces cerevisiae is remodeled in response to various changes in extracellular …

The cytosolic accumulation of mitochondrial precursors is hazardous to cellular fitness and
is associated with a number of diseases. However, it is not observed under physiological …

Summary The Target of Rapamycin (TOR) protein is a Ser/Thr kinase that functions in two
distinct multiprotein complexes: TORC1 and TORC2. These conserved complexes regulate …

The methyltransferase complex (m6A writer), which catalyzes the deposition of N 6-
methyladenosine (m6A) in mRNAs, is highly conserved across most eukaryotic organisms …

Developing methods for accurate detection of RNA modifications remains a major challenge
in epitranscriptomics. Next-generation sequencing-based mapping approaches have …

Yap1 and Skn7 are two yeast transcriptional regulators that co-operate to activate
thioredoxin (TRX2) and thioredoxin reductase (TRR1) in response to redox stress signals …

The structure of many proteins entering the secretory pathway is dependent on stabilization
by disulfide bonds. To support disulfide-linked folding, the endoplasmic reticulum (ER) must …