Organic cations and anions (OCs and OAs, respectively) constitute an extraordinarily
diverse array of compounds of physiological, pharmacological, and toxicological …

Over the last 15 years, a number of transporters that translocate organic cations were
characterized functionally and also identified on the molecular level. Organic cations include …

Polyspecific organic cation transporters in the liver mediate the elimination of a wide array of
endogenous amines and xenobiotics. In contrast to our understanding of the mechanisms of …

▪ Abstract This review focuses on sodium-independent transport systems for organic cations
in small intestine, liver, kidney, and brain. The roles of P-glycoproteins (MDR) and anion …

One of the main functions of the liver, the formation of bile, involves the vectorial transport of
compounds such as bile salts, phospholipids, cholesterol and other organic compounds …

The body is equipped with broad-specificity transporters for the uptake, elimination and
distribution of drugs, environmental toxins and metabolic waste products. The organic cation …

▪ Abstract Organic cation transporters are critical in drug absorption, targeting, and
disposition. It has become increasingly clear that multiple mechanisms are involved in …

Resistance to chemotherapeutic agents is a major cause of treatment failure in patients with
cancer. The primary mechanism leading to a multidrug-resistant phenotype is assumed to …

Several genetic mouse models of opiate sensitivity have been identified or produced in an
attempt to investigate mechanisms underlying individual variation in responses to opiate …

The results of previous work performed in our laboratory using an in situ perfusion technique
in rats and rabbit apical brush border membrane vesicles have suggested that the intestinal …