Natural product interventions for chemotherapy and radiotherapy-induced side effects

QY Zhang, FX Wang, KK Jia, LD Kong - Frontiers in pharmacology, 2018 - frontiersin.org
Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy
are the common cancer treatments. However, the development of adverse effects resulting …

The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer

Z Yang, Q Zhang, L Yu, J Zhu, Y Cao, X Gao - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Triple-negative breast cancer (TNBC) has a poorer
prognosis than other subtypes due to its strong invasion and higher risk of distant …

Cellular senescence: from mechanisms to current biomarkers and senotherapies

V Lucas, C Cavadas, CA Aveleira - Pharmacological Reviews, 2023 - ASPET
An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

Pharmacological and Antioxidant Activities of Rhus coriaria L. (Sumac)

H Alsamri, K Athamneh, G Pintus, AH Eid, R Iratni - Antioxidants, 2021 - mdpi.com
Rhus coriaria L.(Anacardiaceae), commonly known as sumac, is a commonly used spice,
condiment, and flavoring agent, especially in the Mediterranean region. Owing to its …

Plant Derived Bioactive Compounds, Their Anti-Cancer Effects and In Silico Approaches as an Alternative Target Treatment Strategy for Breast Cancer: An Updated …

V Shrihastini, P Muthuramalingam, S Adarshan… - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer is one of the leading causes of death among women
worldwide. Breast cancer may be provoked due to several physical, chemical and …

Autophagy: Mechanisms and therapeutic potential of flavonoids in cancer

X Pang, X Zhang, Y Jiang, Q Su, Q Li, Z Li - Biomolecules, 2021 - mdpi.com
Autophagy, which is a conserved biological process and essential mechanism in
maintaining homeostasis and metabolic balance, enables cells to degrade cytoplasmic …

[HTML][HTML] Mechanisms shaping the role of ERK1/2 in cellular senescence

J Zou, T Lei, P Guo, J Yu, Q Xu… - Molecular …, 2019 - spandidos-publications.com
Senescence is a result of cellular stress and is a potential mechanism for regulating cancer.
As a member of the mitogen‑activated protein kinase family, ERK1/2 (extracellular signal …

Rhus coriaria L. (Sumac), a Versatile and Resourceful Food Spice with Cornucopia of Polyphenols

GES Batiha, OM Ogunyemi, HM Shaheen, FR Kutu… - Molecules, 2022 - mdpi.com
In recent years, utilization of Rhus coriaria L.(sumac) is upgrading not only in their culinary
use and human nutrition, but also in the pharmaceutical industry, food industry and …

Antiproliferative and Antioxidative Bioactive Compounds in Extracts of Marine-Derived Endophytic Fungus Talaromyces purpureogenus

M Kumari, S Taritla, A Sharma… - Frontiers in …, 2018 - frontiersin.org
Endophytic fungi are now recognized as sources of pharmacologically beneficial, novel
bioactive compounds. This study was carried out to evaluate antiproliferative and …

Escin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells in vitro and in vivo

J Zhu, W Yu, B Liu, Y Wang, J Wang, K Xia… - Cell Death & …, 2017 - nature.com
Osteosarcoma is one of the most malignant neoplasms in adolescents, and it generally
develops multidrug resistance. Escin, a natural mixture of triterpene saponins isolated from …