Abstract RABORAL V-RG® is an oral rabies vaccine bait that contains an attenuated
(“modified-live”) recombinant vaccinia virus vector vaccine expressing the rabies virus …

Poxviruses are a highly successful family of pathogens, with variola virus, the causative
agent of smallpox, being the most notable member. Poxviruses are unique among animal …

Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but
eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here …

The efficacy and safety of biological molecules in cancer therapy, such as peptides and
small interfering RNAs (siRNAs), could be markedly increased if high concentrations could …

Pathogen-associated molecular patterns decisively influence antiviral immune responses,
whereas the contribution of endogenous signals of tissue damage, also known as damage …

Modified vaccinia Ankara (MVA), a highly attenuated vaccinia virus strain that has been
safety tested in humans, was evaluated for use as an expression vector. MVA has multiple …

Different passages of the vaccinia virus strain Ankara (CVA wild-type) during attenuation to
MVA (modified vaccinia virus Ankara) have been analysed to detect alterations in the …

Oncolytic viruses are generally designed to be cancer selective on the basis of a single
genetic mutation. JX-594 is a thymidine kinase (TK) gene-inactivated oncolytic vaccinia virus …

Efforts to selectively target and disrupt established tumor vasculature have largely failed to
date. We hypothesized that a vaccinia virus engineered to target cells with activation of the …

Viruses have been engineered for cancer therapy in a variety of ways. Approaches include
non-replicating gene therapy vectors, cancer vaccines and oncolytic viruses, but the clinical …