From synapses to circuits, astrocytes regulate behavior

KA Lyon, NJ Allen - Frontiers in neural circuits, 2022 - frontiersin.org
Astrocytes are non-neuronal cells that regulate synapses, neuronal circuits, and behavior.
Astrocytes ensheath neuronal synapses to form the tripartite synapse where astrocytes …

Oligodendrocyte calcium signaling promotes actin-dependent myelin sheath extension

M Iyer, H Kantarci, MH Cooper, N Ambiel… - Nature …, 2024 - nature.com
Myelin is essential for rapid nerve signaling and is increasingly found to play important roles
in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as …

The role of astrocytes in behaviors related to emotion and motivation

E Shigetomi, S Koizumi - Neuroscience Research, 2023 - Elsevier
Astrocytes are present throughout the brain and intimately interact with neurons and blood
vessels. Three decades of research have shown that astrocytes reciprocally communicate …

A perspective on astrocyte regulation of neural circuit function and animal behavior

J Hirrlinger, A Nimmerjahn - Glia, 2022 - Wiley Online Library
Studies over the past two decades have demonstrated that astrocytes are tightly associated
with neurons and play pivotal roles in neural circuit development, operation, and adaptation …

T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma

RM Carey, DB McMahon, ZA Miller, TB Kim… - Molecular …, 2022 - Wiley Online Library
Better management of head and neck squamous cell carcinomas (HNSCCs) requires a
clearer understanding of tumor biology and disease risk. Bitter taste receptors (T2Rs) have …

Subcellular second messenger networks drive distinct repellent-induced axon behaviors

S Baudet, Y Zagar, F Roche, C Gomez-Bravo… - Nature …, 2023 - nature.com
Second messengers, including cAMP, cGMP and Ca2+ are often placed in an integrating
position to combine the extracellular cues that orient growing axons in the developing brain …

CXCL12 targets the primary cilium cAMP/cGMP ratio to regulate cell polarity during migration

M Atkins, M Wurmser, M Darmon, F Roche… - Nature …, 2023 - nature.com
Directed cell migration requires sustained cell polarisation. In migrating cortical
interneurons, nuclear movements are directed towards the centrosome that organises the …

[HTML][HTML] Looking for guidance–models and methods to study axonal navigation

A Dumoulin, ET Stoeckli - Neuroscience, 2023 - Elsevier
The molecular mechanisms of neural circuit formation have been of interest to Santiago
Ramón y Cajal and thousands of neuroscientists sharing his passion for neural circuits ever …

Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity

M Pozo-Morales, AE Cobham, C Centola… - Life Science …, 2024 - life-science-alliance.org
Starvation causes the accumulation of lipid droplets in the liver, a somewhat counterintuitive
phenomenon that is nevertheless conserved from flies to humans. Much like fatty liver …

High-affinity tuning of single fluorescent protein-type indicators by flexible linker length optimization in topology mutant

Y Hara, A Ichiraku, T Matsuda, A Sakane… - Communications …, 2024 - nature.com
Abstract Genetically encoded Ca2+ indicators (GECIs) are versatile for live imaging of
cellular activities. Besides the brightness and dynamic range of signal change of GECIs …