Pathway and network analysis of cancer genomes
Nature methods, 2015 - nature.com
Genomic information on tumors from 50 cancer types cataloged by the International Cancer
Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently …
Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently …
B cells and tertiary lymphoid structures promote immunotherapy response
Abstract Treatment with immune checkpoint blockade (ICB) has revolutionized cancer
therapy. Until now, predictive biomarkers,,,,,,,,–and strategies to augment clinical response …
therapy. Until now, predictive biomarkers,,,,,,,,–and strategies to augment clinical response …
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
The emergence and global spread of SARS-CoV-2 has resulted in the urgent need for an in-
depth understanding of molecular functions of viral proteins and their interactions with the …
depth understanding of molecular functions of viral proteins and their interactions with the …
Reactome pathway analysis: a high-performance in-memory approach
A Fabregat, K Sidiropoulos, G Viteri, O Forner… - BMC …, 2017 - Springer
Background Reactome aims to provide bioinformatics tools for visualisation, interpretation
and analysis of pathway knowledge to support basic research, genome analysis, modelling …
and analysis of pathway knowledge to support basic research, genome analysis, modelling …
ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization
G Yu, QY He - Molecular BioSystems, 2016 - pubs.rsc.org
Reactome is a manually curated pathway annotation database for unveiling high-order
biological pathways from high-throughput data. ReactomePA is an R/Bioconductor package …
biological pathways from high-throughput data. ReactomePA is an R/Bioconductor package …
From protein-protein interactions to protein co-expression networks: a new perspective to evaluate large-scale proteomic data
The reductionist approach of dissecting biological systems into their constituents has been
successful in the first stage of the molecular biology to elucidate the chemical basis of …
successful in the first stage of the molecular biology to elucidate the chemical basis of …
A circRNA–miRNA–mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma
D Xiong, Y Dang, P Lin, D Wen, R He, D Luo… - Journal of translational …, 2018 - Springer
Abstract Background Circular RNAs (circRNAs) have received increasing attention in human
tumor research. However, there are still a large number of unknown circRNAs that need to …
tumor research. However, there are still a large number of unknown circRNAs that need to …
CD4+ effector T cells accelerate Alzheimer's disease in mice
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder
characterized by pathological deposition of misfolded self-protein amyloid beta (Aβ) which in …
characterized by pathological deposition of misfolded self-protein amyloid beta (Aβ) which in …
Therapeutic targeting of RNA splicing catalysis through inhibition of protein arginine methylation
Cancer-associated mutations in genes encoding RNA splicing factors (SFs) commonly occur
in leukemias, as well as in a variety of solid tumors, and confer dependence on wild-type …
in leukemias, as well as in a variety of solid tumors, and confer dependence on wild-type …
Gateways to the FANTOM5 promoter level mammalian expression atlas
M Lizio, J Harshbarger, H Shimoji, J Severin… - Genome biology, 2015 - Springer
The FANTOM5 project investigates transcription initiation activities in more than 1,000
human and mouse primary cells, cell lines and tissues using CAGE. Based on manual …
human and mouse primary cells, cell lines and tissues using CAGE. Based on manual …