Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis

BV Lananna, CA McKee, MW King… - Science translational …, 2020 - science.org
Regulation of glial activation and neuroinflammation are critical factors in the pathogenesis
of Alzheimer's disease (AD). YKL-40, a primarily astrocytic protein encoded by the gene …

Glial activation and inflammation along the Alzheimer's disease continuum

K Nordengen, BE Kirsebom, K Henjum… - Journal of …, 2019 - Springer
Background Neuronal and glial cell interaction is essential for synaptic homeostasis and
may be affected in Alzheimer's disease (AD). We measured cerebrospinal fluid (CSF) …

The neuroinflammatory biomarker YKL-40 for neurodegenerative diseases: advances in development

F Baldacci, S Lista, G Palermo, FS Giorgi… - Expert review of …, 2019 - Taylor & Francis
Introduction: Neuroinflammation is a common pathophysiological mechanism in
neurodegenerative diseases (ND). Cerebrospinal fluid (CSF) YKL-40 has recently been …

The chitinases as biomarkers for amyotrophic lateral sclerosis: signals from the CNS and beyond

N Gaur, C Perner, OW Witte, J Grosskreutz - Frontiers in Neurology, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative condition, most widely
characterized by the selective vulnerability of motor neurons and the poor life expectancy of …

Multi‐omic landscaping of human midbrains identifies disease‐relevant molecular targets and pathways in advanced‐stage Parkinson's disease

L Caldi Gomes, A Galhoz, G Jain… - Clinical and …, 2022 - Wiley Online Library
Background Parkinson's disease (PD) is the second most common neurodegenerative
disorder whose prevalence is rapidly increasing worldwide. The molecular mechanisms …

Cerebrospinal fluid YKL-40 and chitotriosidase levels in frontotemporal dementia vary by clinical, genetic and pathological subtype

IOC Woollacott, JM Nicholas, C Heller… - Dementia and Geriatric …, 2020 - karger.com
Background: Chronic glial dysfunction may contribute to the pathogenesis of frontotemporal
dementia (FTD). Cerebrospinal fluid (CSF) levels of glia-derived proteins YKL-40 and …

Genetic architecture of plasma Alzheimer disease biomarkers

J Bradley, P Gorijala, SE Schindler… - Human molecular …, 2023 - academic.oup.com
Genome-wide association studies (GWAS) of cerebrospinal fluid (CSF) Alzheimer's Disease
(AD) biomarker levels have identified novel genes implicated in disease risk, onset and …

Neuroimaging feature terminology: A controlled terminology for the annotation of brain imaging features

A Iyappan, E Younesi, A Redolfi… - Journal of …, 2017 - content.iospress.com
Ontologies and terminologies are used for interoperability of knowledge and data in a
standard manner among interdisciplinary research groups. Existing imaging ontologies …

Neues zu biologischen Markern bei Autoimmunenzephalitis

N Hansen, C Timäus - Clinical Epileptology, 2020 - search.proquest.com
Neues zu biologischen Markern bei Autoimmunenzephalitis Page 1 Zeitschrift für
Epileptologie Leitthema Z. Epileptol. 2020 · 33:288–293 https://doi.org/10.1007/s10309-020-00356-2 …

Association of the polymorphisms and plasma level of CHI3L1 with Alzheimer's disease in the Chinese Han population: a case-control study

QH Dai, DK Gong - Neuropsychobiology, 2018 - karger.com
Objective: To investigate whether the polymorphisms and plasma level of chitinase-3-like
protein 1 (CHI3L1) are associated with Alzheimer's disease (AD) in the Chinese Han …