Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis
BV Lananna, CA McKee, MW King… - Science translational …, 2020 - science.org
Regulation of glial activation and neuroinflammation are critical factors in the pathogenesis
of Alzheimer's disease (AD). YKL-40, a primarily astrocytic protein encoded by the gene …
of Alzheimer's disease (AD). YKL-40, a primarily astrocytic protein encoded by the gene …
Glial activation and inflammation along the Alzheimer's disease continuum
K Nordengen, BE Kirsebom, K Henjum… - Journal of …, 2019 - Springer
Background Neuronal and glial cell interaction is essential for synaptic homeostasis and
may be affected in Alzheimer's disease (AD). We measured cerebrospinal fluid (CSF) …
may be affected in Alzheimer's disease (AD). We measured cerebrospinal fluid (CSF) …
The neuroinflammatory biomarker YKL-40 for neurodegenerative diseases: advances in development
Introduction: Neuroinflammation is a common pathophysiological mechanism in
neurodegenerative diseases (ND). Cerebrospinal fluid (CSF) YKL-40 has recently been …
neurodegenerative diseases (ND). Cerebrospinal fluid (CSF) YKL-40 has recently been …
The chitinases as biomarkers for amyotrophic lateral sclerosis: signals from the CNS and beyond
Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative condition, most widely
characterized by the selective vulnerability of motor neurons and the poor life expectancy of …
characterized by the selective vulnerability of motor neurons and the poor life expectancy of …
Multi‐omic landscaping of human midbrains identifies disease‐relevant molecular targets and pathways in advanced‐stage Parkinson's disease
Background Parkinson's disease (PD) is the second most common neurodegenerative
disorder whose prevalence is rapidly increasing worldwide. The molecular mechanisms …
disorder whose prevalence is rapidly increasing worldwide. The molecular mechanisms …
Cerebrospinal fluid YKL-40 and chitotriosidase levels in frontotemporal dementia vary by clinical, genetic and pathological subtype
IOC Woollacott, JM Nicholas, C Heller… - Dementia and Geriatric …, 2020 - karger.com
Background: Chronic glial dysfunction may contribute to the pathogenesis of frontotemporal
dementia (FTD). Cerebrospinal fluid (CSF) levels of glia-derived proteins YKL-40 and …
dementia (FTD). Cerebrospinal fluid (CSF) levels of glia-derived proteins YKL-40 and …
Genetic architecture of plasma Alzheimer disease biomarkers
J Bradley, P Gorijala, SE Schindler… - Human molecular …, 2023 - academic.oup.com
Genome-wide association studies (GWAS) of cerebrospinal fluid (CSF) Alzheimer's Disease
(AD) biomarker levels have identified novel genes implicated in disease risk, onset and …
(AD) biomarker levels have identified novel genes implicated in disease risk, onset and …
Neuroimaging feature terminology: A controlled terminology for the annotation of brain imaging features
A Iyappan, E Younesi, A Redolfi… - Journal of …, 2017 - content.iospress.com
Ontologies and terminologies are used for interoperability of knowledge and data in a
standard manner among interdisciplinary research groups. Existing imaging ontologies …
standard manner among interdisciplinary research groups. Existing imaging ontologies …
Neues zu biologischen Markern bei Autoimmunenzephalitis
N Hansen, C Timäus - Clinical Epileptology, 2020 - search.proquest.com
Neues zu biologischen Markern bei Autoimmunenzephalitis Page 1 Zeitschrift für
Epileptologie Leitthema Z. Epileptol. 2020 · 33:288–293 https://doi.org/10.1007/s10309-020-00356-2 …
Epileptologie Leitthema Z. Epileptol. 2020 · 33:288–293 https://doi.org/10.1007/s10309-020-00356-2 …
Association of the polymorphisms and plasma level of CHI3L1 with Alzheimer's disease in the Chinese Han population: a case-control study
QH Dai, DK Gong - Neuropsychobiology, 2018 - karger.com
Objective: To investigate whether the polymorphisms and plasma level of chitinase-3-like
protein 1 (CHI3L1) are associated with Alzheimer's disease (AD) in the Chinese Han …
protein 1 (CHI3L1) are associated with Alzheimer's disease (AD) in the Chinese Han …