[HTML][HTML] Planarian nociception: Lessons from a scrunching flatworm
G Reho, V Lelièvre, H Cadiou - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
In addition to being studied for their exceptional regeneration abilities, planarians (ie,
flatworms) have also been extensively used in the context of pharmacological experiments …
flatworms) have also been extensively used in the context of pharmacological experiments …
[HTML][HTML] The endocannabinoid system and invertebrate neurodevelopment and regeneration
TL Clarke, RL Johnson, JJ Simone… - International journal of …, 2021 - mdpi.com
Cannabis has long been used for its medicinal and psychoactive properties. With the
relatively new adoption of formal medicinal cannabis regulations worldwide, the study of …
relatively new adoption of formal medicinal cannabis regulations worldwide, the study of …
Dugesia japonica is the best suited of three planarian species for high-throughput toxicology screening
D Ireland, V Bochenek, D Chaiken, C Rabeler, S Onoe… - Chemosphere, 2020 - Elsevier
High-throughput screening (HTS) using new approach methods is revolutionizing
toxicology. Asexual freshwater planarians are a promising invertebrate model for …
toxicology. Asexual freshwater planarians are a promising invertebrate model for …
[HTML][HTML] Differences in neurotoxic outcomes of organophosphorus pesticides revealed via multi-dimensional screening in adult and regenerating planarians
Organophosphorus pesticides (OPs) are a chemically diverse class of commonly used
insecticides. Epidemiological studies suggest that low dose chronic prenatal and infant …
insecticides. Epidemiological studies suggest that low dose chronic prenatal and infant …
New worm on the block: Planarians in (neuro) toxicology
D Ireland, EMS Collins - Current protocols, 2022 - Wiley Online Library
Traditional mammalian testing is too time‐and cost‐intensive to keep up with the large
number of environmental chemicals needing assessment. This has led to a dearth of …
number of environmental chemicals needing assessment. This has led to a dearth of …
Adult and regenerating planarians respond differentially to chronic drug exposure
K Bayingana, D Ireland, E Rosenthal, C Rabeler… - Neurotoxicology and …, 2023 - Elsevier
There is a lack of data on the effects of chronic exposure to common drugs and stimulants on
the developing nervous system. Freshwater planarians have emerged as a useful …
the developing nervous system. Freshwater planarians have emerged as a useful …
A miniaturized electrothermal array for rapid analysis of temperature preference behaviors in ecology and ecotoxicology
Due to technical limitations, there have been minimal studies performed on thermal
preferences and thermotactic behaviors of aquatic ectotherm species commonly used in …
preferences and thermotactic behaviors of aquatic ectotherm species commonly used in …
[HTML][HTML] Planarian fragments behave as whole animals
D Le, Z Sabry, A Chandra, WB Kristan, EMS Collins - Current Biology, 2021 - cell.com
Behavioral responses of freshwater planarians have been studied for over a century. 1 In
recent decades, behavior has been used as a readout to study planarian development and …
recent decades, behavior has been used as a readout to study planarian development and …
Planarians as a model to study neurotoxic agents
D Ireland, EMS Collins - Advances in Neurotoxicology, 2023 - Elsevier
The developing brain is more vulnerable to chemicals than the adult brain, but
environmental chemicals have only been sparingly tested for developmental neurotoxicity …
environmental chemicals have only been sparingly tested for developmental neurotoxicity …
Behavioral and pharmacological characterization of planarian nociception
Introduction Pain mostly arises because specialized cells called nociceptors detect harmful
or potentially harmful stimuli. In lower animals with less convoluted nervous system, these …
or potentially harmful stimuli. In lower animals with less convoluted nervous system, these …