Anti-inflammatory agents suppress inflammatory mediators such as prostaglandins,
prostacyclins, cytokines, thromboxane, histamine, bradykinins, COX-I and COX-II, 5-LOX …

Background: Alzheimer's disease is the main reason for dementia among the older section
of the community. Administration of drugs through oral route to the patients suffering from …

A new series of murrayanine based pyrimidine derivatives were synthesized from the
previously reported starting material, known as murrayanine-chalcone and urea as the …

Inspiring and motivating from the above fact that hybridization by incorporating several
heterocyclic scaffolds often results in amplification of pharmacological activity, a hybrid was …

Background: Glimepiride has limited aqueous solubility and majorly suffers from
bioavailability issues that eventually reduce the pharmacotherapeutic potentials of the …

Introduction: Developing and optimizing isocratic HPLC methods is a difficult procedure that
requires simultaneous determination of several factors. Objective: To develop a simple …

Background: Fenofibrate is having a broad spectrum lipid-lowering activity that produces
substantial reductions in the fatty components. The drug belongs to BCS Class-II and …

ABSTRACT Introduction: Cyclooxygenases (COXs) are the enzymes that specifically
influence the production (minute quantities) of prostaglandins and their derivatives, which …

In the previous research done, uracil moiety substituted hippuric acid containing 1, 3, 4-
thiadiazole scaffold was rationally designed, synthesized, and screened for anti-diabetic …

Background: Carbamazepine is used in the management of seizures by decreasing the
central nervous system disorganized electrical activity and also has analgesic properties. It …