Toward automated enzymatic synthesis of oligosaccharides

L Wen, G Edmunds, C Gibbons, J Zhang… - Chemical …, 2018 - ACS Publications
Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …

Advances and challenges in biotechnological production of chondroitin sulfate and its oligosaccharides

W Zhang, R Xu, J Chen, H Xiong, Y Wang… - International journal of …, 2023 - Elsevier
Chondroitin sulfate (CS) is a member of glycosaminoglycans (GAGs) and has critical
physiological functions. CS is widely applied in medical and clinical fields. Currently, the …

Complete biosynthesis of a sulfated chondroitin in Escherichia coli

A Badri, A Williams, A Awofiranye, P Datta… - Nature …, 2021 - nature.com
Sulfated glycosaminoglycans (GAGs) are a class of important biologics that are currently
manufactured by extraction from animal tissues. Although such methods are unsustainable …

Biosynthesis of non-animal chondroitin sulfate from methanol using genetically engineered Pichia pastoris

X Jin, W Zhang, Y Wang, J Sheng, R Xu, J Li, G Du… - Green …, 2021 - pubs.rsc.org
Chondroitin sulfate (CS) is widely applied in the medical, clinical, and nutraceutical fields.
However, all commercialized CS is extracted from animal tissues, which is associated with …

[HTML][HTML] Heterologous production of chondroitin

MR Couto, JL Rodrigues, LR Rodrigues - Biotechnology Reports, 2022 - Elsevier
Chondroitin sulfate (CS) is a glycosaminoglycan with a broad range of applications being a
popular dietary supplement for osteoarthritis. Usually, CS is extracted from animal sources …

Microbial synthesis of glycosaminoglycans and their oligosaccharides

K Liu, L Guo, X Chen, L Liu, C Gao - Trends in Microbiology, 2023 - cell.com
Compared with chemical synthesis and tissue extraction methods, microbial synthesis of
glycosaminoglycans (GAGs) is attractive because of the advantages of eco-friendly …

The road to animal-free glycosaminoglycan production: current efforts and bottlenecks

A Badri, A Williams, RJ Linhardt, MAG Koffas - Current opinion in …, 2018 - Elsevier
Highlights•Animal extraction is monopolizing the glycosaminoglycan (GAG) production
industry.•Focus on synthetic GAGs using chemical, chemoenzymatic and biosynthesis …

Chondroitin sulfate and its derivatives: A review of microbial and other production methods

AE Awofiranye, J Hudson, AD Tithi, RJ Linhardt… - Fermentation, 2022 - mdpi.com
Chondroitin sulfate (CS) is widely used across the world as a nutraceutical and
pharmaceutical. Its high demand and potential limitations in current methods of extraction …

Bio-based strategies for producing glycosaminoglycans and their oligosaccharides

Z Kang, Z Zhou, Y Wang, H Huang, G Du, J Chen - Trends in biotechnology, 2018 - cell.com
Glycosaminoglycans (GAGs) and their oligosaccharides have attracted extensive attention
because of their wide applications in cosmetics, health, and clinical treatment of, for …

Unraveling the intricacies of glycosaminoglycan biosynthesis: Decoding the molecular symphony in understanding complex polysaccharide assembly

ZY Yao, JS Gong, JY Jiang, C Su, WH Zhao… - Biotechnology …, 2024 - Elsevier
Glycosaminoglycans (GAGs) are extensively utilized in clinical, cosmetic, and healthcare
field, as well as in the treatment of thrombosis, osteoarthritis, rheumatism, and cancer. The …