Cell death and injury often lead to release or exposure of intracellular molecules called
damage-associated molecular patterns (DAMPs) or cell death-associated molecules. These …

Synthetically derived peptide-based biomaterials are in many instances capable of
mimicking the structure and function of their full-length endogenous counterparts. Combine …

Inflammatory cytokines can sometimes trigger depression in humans, are often associated
with depression, and can elicit some behaviors in animals that are homologous to major …

Highlights•The hCoVs induce inflammatory pneumonia, which in turn may cause ALI and
ARDS.•The inflammatory process may be caused by dysregulated uPA/uPAR …

Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-
inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease …

Inflammation is the body's way of defending itself against noxious stimuli and pathogens.
Under normal circumstances, the body is able to eliminate the insult and subsequently …

Background—Platelet activation at sites of vascular injury is essential for hemostasis, but it is
also a major pathomechanism underlying ischemic injury. Because anti-inflammatory …

Resolution of inflammation is an active process involving a novel category of lipid factors
known as specialized pro-resolving lipid mediators, which includes Resolvin D1 (RvD1) …

Under physiological conditions the initiation, duration and amplitude of inflammatory
responses are tightly regulated to ensure the restoration of homeostasis. The resolution of …

Eicosanoids are biologically active lipids in both physiologic and pathophysiologic
situations. These mediators rapidly generate at sites of inflammation and act through specific …