Ingestible Sensor Based on Fluorescent Gold Nanopaticles and Molecularly Imprinted Polymers on Thread for Localized Quantification of Escherichia Coli in the …

K Khachornsakkul, R Del‐Rio‐Ruiz… - Advanced Functional …, 2024 - Wiley Online Library
The small intestinal (SI) microbiota plays an important role in human health and disease.
Current methods based on fecal analysis do not provide an accurate representation of the SI …

Poly(vinylpyridine-co-vinylpyridine N-oxide) Excipients Mediate Rapid Dissolution and Sustained Supersaturation of Posaconazole Amorphous Solid Dispersions

YS Liu, J Della Rocca, L Schenck… - Molecular …, 2024 - ACS Publications
The chemical structure of excipients molecularly mixed in an amorphous solid dispersion
(ASD) has a significant impact on properties of the ASD including dissolution behavior …

Modified Release 3D-Printed Capsules Containing a Ketoprofen Self-Nanoemulsifying System for Personalized Medical Application

B Shaqour, H Natsheh, N Kittana… - ACS Biomaterials …, 2024 - ACS Publications
This study explores the realm of personalized medicine by investigating the utilization of 3D-
printed dosage forms, specifically focusing on patient-specific enteric capsules designed for …

Electromagnetic drop-on-demand (DoD) technology as an innovative platform for amorphous solid dispersion production

AM Helmy, A Lu, I Duggal, KP Rodrigues… - International Journal of …, 2024 - Elsevier
Production of amorphous solid dispersions (ASDs) is an effective strategy to promote the
solubility and bioavailability of poorly water soluble medicinal substances. In general, ASD …

[HTML][HTML] Drug dissolution and transit in a heterogenous gastric chyme after fed administration: Semi-mechanistic modeling and simulations for an immediate-release …

D Danielak, M Gajda, T Bołtromiuk… - European Journal of …, 2024 - Elsevier
Mathematical models that treat the fed stomach content as a uniform entity emptied with a
constant rate may not suffice to explain pharmacokinetic profiles recorded in clinical trials. In …

[HTML][HTML] Application of a Novel Dissolution Medium with Lipids for In Vitro Simulation of the Postprandial Gastric Content

T Felicijan, I Rakoše, M Prislan, I Locatelli, M Bogataj… - Pharmaceutics, 2024 - mdpi.com
Food can change various physiological parameters along the gastrointestinal tract,
potentially impacting postprandial drug absorption. It is thus important to consider different in …

[HTML][HTML] Concordance of vacuum compression molding with spray drying in screening of amorphous solid dispersions of itraconazole

G Dhumal, D Treffer, JE Polli - International Journal of Pharmaceutics, 2024 - Elsevier
Spray drying is a well-established method for screening spray dried dispersions (SDDs) but
is material consuming, and the amorphous solid dispersions (ASDs) formed have low bulk …

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

HA Tsai, TM Shih, T Tsai, JW Hu, YA Lai… - Beilstein Journal of …, 2024 - beilstein-journals.org
Abstract ᴅ-cycloserine (DCS), an FDA-approved medicine for the treatment of tuberculosis,
is also a partial agonist at the glycine recognition site of N-methyl-ᴅ-aspartate (NMDA) …