Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
worldwide. With no Food and Drug Administration approved drugs, current treatment options …

Background Nonalcoholic fatty liver disease (NAFLD) comprises hepatic alterations with
increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic …

The liver constitutes a key organ in systemic metabolism, contributing substantially to the
development of insulin resistance and type 2 diabetes mellitus (T2DM). The mechanisms …

Magnetic resonance imaging and spectroscopic techniques are widely used in humans both
for clinical diagnostic applications and in basic research areas such as cognitive …

Clinical and pathophysiological studies have shown type 2 diabetes to be a condition mainly
caused by excess, yet reversible, fat accumulation in the liver and pancreas. Within the liver …

Type 2 diabetes mellitus (T2DM) is a systemic disease characterized by hyperglycemia,
hyperlipidemia, and organismic insulin resistance. This pathological shift in both circulating …

The association of hepatic mitochondrial function with insulin resistance and non-alcoholic
fatty liver (NAFL) or steatohepatitis (NASH) remains unclear. This study applied high …

Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic
signaling molecule involved in cardiovascular and metabolic regulation. More recently, an …

Accumulating evidence indicates that obesity is closely associated with an increased risk of
metabolic diseases such as insulin resistance, type 2 diabetes, dyslipidemia and …

Non-alcoholic fatty liver disease (NAFLD) comprises fatty liver (steatosis), non-alcoholic
steatohepatitis (NASH) and fibrosis/cirrhosis and may lead to end-stage liver failure or …