Natural killer (NK) cells survey host tissues for signs of infection, transformation or stress
and, true to their name, kill target cells that have become useless or are detrimental to the …

The peripheral mature T cell pool is regulated by complex homeostatic mechanisms. Naive
T cells are maintained by interleukin-7 (IL-7) and T cell receptor (TCR) signaling from …

To understand why cancer vaccine–induced T cells often do not eradicate tumors, we
studied immune responses in mice vaccinated with gp100 melanoma peptide in incomplete …

Differentiation and fate of virus-specific CD8+ T cells after cessation of chronic antigen
stimulation is unclear. Here we show that a TCF1+ CD127+ PD1+ hepatitis C virus (HCV) …

The antiapoptotic protein BCL2 plays critical roles in regulating lymphocyte development
and immune responses, and has also been implicated in tumorigenesis and tumor survival …

Tissue resident memory (Trm) CD8 T cells represent a newly described memory T cell
population. We have previously characterized a population of Trm cells that persists within …

The ability to develop and sustain populations of memory T cells after infection or
immunization is a hallmark of the adaptive immune response and a basis for protective …

Foxo transcription factors have a conserved role in the adaptation of cells and organisms to
nutrient and growth factor availability. Here we show that Foxo1 has a crucial, nonredundant …

The peripheral naive T cell pool is fairly stable in number, diversity and functional
competence in the absence of vigorous immune responses. However, this apparent …

Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to
elucidate the mechanisms that govern the formation of memory T cells and their ability to …