Tightly orchestrated programmed cell death (PCD) signalling events occur during normal
neuronal development in a spatially and temporally restricted manner to establish the neural …

Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide. Motor deficits usually associated with PD correlate with dopaminergic axonal …

Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Symptoms of Parkinson's disease arise due to neuronal loss in multiple brain regions,
especially dopaminergic neurons in the substantia nigra pars compacta. Current therapies …

Neurodegenerative disorders affect almost 30 million individuals leading to disability and
death. These disorders are characterized by pathological changes in disease-specific areas …

A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …

Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the
substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic …

Oxidative stress contributes to the cascade leading to dopamine cell degeneration in
Parkinson's disease (PD). However, oxidative stress is intimately linked to other components …

Multiple roles for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) have been recently
appreciated. In addition to the cytoplasm where the majority of GAPDH is located under the …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by a preferential
loss of the dopaminergic neurons of the substantia nigrapars compacta. Although the …