Surface modification of lipid-based nanoparticles

Y Xu, T Fourniols, Y Labrak, V Préat, A Beloqui… - ACS …, 2022 - ACS Publications
There is a growing interest in the development of lipid-based nanocarriers for multiple
purposes, including the recent increase of these nanocarriers as vaccine components …

Endosomal escape pathways for delivery of biologicals

AK Varkouhi, M Scholte, G Storm, HJ Haisma - Journal of Controlled …, 2011 - Elsevier
Despite continuous improvements in delivery systems, the development of methods for
efficient and specific delivery of targeted therapeutic agents still remains an issue in …

Strategies in the design of endosomolytic agents for facilitating endosomal escape in nanoparticles

A Ahmad, JM Khan, S Haque - Biochimie, 2019 - Elsevier
Nanoparticles (NPs) are one of the leading and promising technologies for gene and drug
delivery. However, despite continuous advancements in the delivery of NPs, endosomal …

Nanotherapy for posterior eye diseases

IP Kaur, S Kakkar - Journal of Controlled Release, 2014 - Elsevier
It is assumed that more than 50% of the most enfeebling ocular diseases have their origin in
the posterior segment. Furthermore, most of these diseases lead to partial or complete …

Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier

A Beloqui, MÁ Solinís, AR Gascón… - Journal of Controlled …, 2013 - Elsevier
The aims of this work were (i) to evaluate the potential of nanostructured lipid carriers
(NLCs) as a tool to enhance the oral bioavailability of poorly soluble compounds using …

A novel cationic niosome formulation for gene delivery to the retina

G Puras, M Mashal, J Zárate, M Agirre, E Ojeda… - Journal of Controlled …, 2014 - Elsevier
Niosomes represent a recent promising approach for gene delivery purposes. We
elaborated on a novel niosome formulation based on the 2, 3-di (tetradecyloxy) propan-1 …

Applications of lipid nanoparticles in gene therapy

A del Pozo-Rodriguez, MÁ Solinís… - European Journal of …, 2016 - Elsevier
Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have been
recognized, among the large number of non-viral vectors for gene transfection, as an …

Nanostructured lipid carriers (NLC): the second generation of solid lipid nanoparticles

RH Müller, U Alexiev, P Sinambela… - … chemical methods in …, 2016 - Springer
Solid lipid nanoparticles (SLN) were invented in 1991 as a delivery system combining
advantages of other nanoparticulate systems and at the same time avoiding/minimizing …

Nanoparticle-based drug delivery: case studies for cancer and cardiovascular applications

P Galvin, D Thompson, KB Ryan, A McCarthy… - Cellular and Molecular …, 2012 - Springer
Nanoparticles (NPs) comprised of nanoengineered complexes are providing new
opportunities for enabling targeted delivery of a range of therapeutics and combinations. A …

Structural recovery of the retina in a retinoschisin-deficient mouse after gene replacement therapy by solid lipid nanoparticles

PS Apaolaza, A del Pozo-Rodríguez, MA Solinís… - Biomaterials, 2016 - Elsevier
X-linked juvenile retinoschisis (XLRS) is a retinal degenerative disorder caused by
mutations in the RS1 gene encoding a protein termed retinoschisin. The disease is an …