Pancreatic ductal adenocarcinoma (PDA) is among the most immune-resistant tumor types.
Its unique genomic landscape shaped by oncogenic drivers promotes immune suppression …

Immunotherapy has emerged as an effective strategy for the prevention and treatment of a
variety of diseases, including cancer, infectious diseases, inflammatory diseases, and …

Radiotherapy plays a central part in curing cancer. For decades, most research on
improving treatment outcomes has focused on modulating radiation-induced biological …

Tumour-promoting inflammation is considered one of the enabling characteristics of cancer
development. Chronic inflammatory disease increases the risk of some cancers, and strong …

Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number
of genes that are involved in important physiological processes, including survival …

Cancer immunotherapy evolved as a new treatment modality to eradicate tumor cells and
has gained in popularity after its successful clinical transition. By activating antigen …

Innate immune receptors such as toll-like receptors (TLRs) provide critical molecular links
between innate cells and adaptive immune responses. Here, we studied the CD40 pathway …

Radiotherapy is one of the most common treatment modalities for controlling a wide range of
tumors. However, it has been shown that radiotherapy alone is unable to completely …

Despite enormous progress in radiation technologies (high precision image-guided
irradiation, proton irradiation, heavy ion irradiation) and radiotherapeutic concepts …

Radiation therapy (RT) is a well-established but still under optimization branch of Cancer
Therapy (CT). RT uses electromagnetic waves or charged particles in order to kill malignant …