Lung transplantation is the optimal treatment for selected patients with end-stage chronic
lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to …

Innate lymphoid cells (ILCs) are generated early during ontogeny and persist predominantly
as tissue-resident cells. Here, we examined how ILCs are maintained and renewed within …

Allogeneic transplantation of foreign organs or tissues has lifesaving potential, but can lead
to serious complications. After solid organ transplantation, immune-mediated rejection …

The site of transition between tissue-resident memory (TRM) and circulating phenotypes of T
cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of …

Tissue-resident lymphocytes (TRLs) are critical for local protection against viral pathogens in
peripheral tissue. However, it is unclear if TRLs perform a similar role in transplanted organs …

Although human twin studies have revealed the combined contribution of heritable and
environmental factors in shaping immune system variability in blood, the contribution of …

Although innate lymphoid cells (ILCs) play fundamental roles in mucosal barrier functionality
and tissue homeostasis, ILC-related mechanisms underlying intestinal barrier function …

Escherichia coli and Klebsiella pneumoniae are opportunistic pathogens that are commonly
associated with infections at mucosal surfaces, such as the lung or the gut. The host …

Innate lymphoid cells (ILCs) are a family of lymphocytes with essential roles in tissue
homeostasis and immunity. Along with other tissue-resident immune populations, distinct …

Organ fibrosis caused by chronic allograft rejection is a major concern in the field of
transplantation. Macrophage-to-myofibroblast transition plays a critical role in chronic …