Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle
S Bos, L Milross, AJ Filby, R Vos… - European Respiratory …, 2022 - Eur Respiratory Soc
Lung transplantation is the optimal treatment for selected patients with end-stage chronic
lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to …
lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to …
[HTML][HTML] In situ maturation and tissue adaptation of type 2 innate lymphoid cell progenitors
Innate lymphoid cells (ILCs) are generated early during ontogeny and persist predominantly
as tissue-resident cells. Here, we examined how ILCs are maintained and renewed within …
as tissue-resident cells. Here, we examined how ILCs are maintained and renewed within …
New insights into graft-versus-host disease and graft rejection
E Perkey, I Maillard - Annual Review of Pathology: Mechanisms …, 2018 - annualreviews.org
Allogeneic transplantation of foreign organs or tissues has lifesaving potential, but can lead
to serious complications. After solid organ transplantation, immune-mediated rejection …
to serious complications. After solid organ transplantation, immune-mediated rejection …
Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes
The site of transition between tissue-resident memory (TRM) and circulating phenotypes of T
cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of …
cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of …
[HTML][HTML] Virus-specific TRM cells of both donor and recipient origin reside in human kidney transplants
DM Hullegie-Peelen, HT Mora, DA Hesselink… - JCI insight, 2023 - ncbi.nlm.nih.gov
Tissue-resident lymphocytes (TRLs) are critical for local protection against viral pathogens in
peripheral tissue. However, it is unclear if TRLs perform a similar role in transplanted organs …
peripheral tissue. However, it is unclear if TRLs perform a similar role in transplanted organs …
Tissue-specific nonheritable influences drive endometrial immune system variation
Although human twin studies have revealed the combined contribution of heritable and
environmental factors in shaping immune system variability in blood, the contribution of …
environmental factors in shaping immune system variability in blood, the contribution of …
[HTML][HTML] Type 3 innate lymphoid cells are associated with a successful intestinal transplant
J Kang, K Loh, L Belyayev, P Cha, M Sadat… - American Journal of …, 2021 - Elsevier
Although innate lymphoid cells (ILCs) play fundamental roles in mucosal barrier functionality
and tissue homeostasis, ILC-related mechanisms underlying intestinal barrier function …
and tissue homeostasis, ILC-related mechanisms underlying intestinal barrier function …
[HTML][HTML] Innate lymphoid cell type 3–derived interleukin-22 boosts lipocalin-2 production in intestinal epithelial cells via synergy between STAT3 and NF-κB
M Coorens, A Rao, SK Gräfe, D Unelius… - Journal of Biological …, 2019 - ASBMB
Escherichia coli and Klebsiella pneumoniae are opportunistic pathogens that are commonly
associated with infections at mucosal surfaces, such as the lung or the gut. The host …
associated with infections at mucosal surfaces, such as the lung or the gut. The host …
Protective and pathogenic functions of innate lymphoid cells in transplantation
Innate lymphoid cells (ILCs) are a family of lymphocytes with essential roles in tissue
homeostasis and immunity. Along with other tissue-resident immune populations, distinct …
homeostasis and immunity. Along with other tissue-resident immune populations, distinct …
[HTML][HTML] Intragraft immune cells: accomplices or antagonists of recipient-derived macrophages in allograft fibrosis?
X Li, J Wu, S Zhu, Q Wei, L Wang, J Chen - Cellular and Molecular Life …, 2023 - Springer
Organ fibrosis caused by chronic allograft rejection is a major concern in the field of
transplantation. Macrophage-to-myofibroblast transition plays a critical role in chronic …
transplantation. Macrophage-to-myofibroblast transition plays a critical role in chronic …