Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine
Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …
between the biophysical tumor microenvironment and genetic regulation has significant …
Computational modelling of drug delivery to solid tumour: Understanding the interplay between chemotherapeutics and biological system for optimised delivery …
Drug delivery to solid tumour involves multiple physiological, biochemical and biophysical
processes taking place across a wide range of length and time scales. The therapeutic …
processes taking place across a wide range of length and time scales. The therapeutic …
Effects of endothelial cell proliferation and migration rates in a computational model of sprouting angiogenesis
Angiogenesis, the recruitment of new blood vessels, is a critical process for the growth,
expansion, and metastatic dissemination of developing tumors. Three types of cells make up …
expansion, and metastatic dissemination of developing tumors. Three types of cells make up …
Spatiotemporal multi-scale modeling of radiopharmaceutical distributions in vascularized solid tumors
We present comprehensive mathematical modeling of radiopharmaceutical spatiotemporal
distributions within vascularized solid tumors. The novelty of the presented model is at …
distributions within vascularized solid tumors. The novelty of the presented model is at …
[HTML][HTML] A comprehensive review on modeling aspects of infusion-based drug delivery in the brain
Brain disorders represent an ever-increasing health challenge worldwide. While
conventional drug therapies are less effective due to the presence of the blood-brain barrier …
conventional drug therapies are less effective due to the presence of the blood-brain barrier …
Effect of tumor shape and size on drug delivery to solid tumors
Tumor shape and size effect on drug delivery to solid tumors are studied, based on the
application of the governing equations for fluid flow, ie, the conservation laws for mass and …
application of the governing equations for fluid flow, ie, the conservation laws for mass and …
Insights into infusion-based targeted drug delivery in the brain: perspectives, challenges and opportunities
Targeted drug delivery in the brain is instrumental in the treatment of lethal brain diseases,
such as glioblastoma multiforme, the most aggressive primary central nervous system …
such as glioblastoma multiforme, the most aggressive primary central nervous system …
Heterogeneous mechanical stress and interstitial fluid flow predictions derived from DCE-MRI for Rat U251N orthotopic gliomas
JA Rey, KG Spanick, G Cabral… - Annals of biomedical …, 2024 - Springer
Mechanical stress and fluid flow influence glioma cell phenotype in vitro, but measuring
these quantities in vivo continues to be challenging. The purpose of this study was to predict …
these quantities in vivo continues to be challenging. The purpose of this study was to predict …
Convection-enhanced delivery of antiangiogenic drugs and liposomal cytotoxic drugs to heterogeneous brain tumor for combination therapy
Simple Summary Although developed anticancer drugs have shown desirable effects in
preclinical trials, the clinical efficacy of chemotherapy against brain cancer remains …
preclinical trials, the clinical efficacy of chemotherapy against brain cancer remains …
Computational modeling of interstitial fluid pressure and velocity in head and neck cancer based on dynamic contrast-enhanced magnetic resonance imaging …
E LoCastro, R Paudyal, Y Mazaheri, V Hatzoglou… - …, 2020 - pmc.ncbi.nlm.nih.gov
We developed and tested the feasibility of computational fluid modeling (CFM) based on
dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for quantitative …
dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for quantitative …