The emerging use of zebrafish to model metabolic disease
A Seth, DL Stemple, I Barroso - Disease models & …, 2013 - journals.biologists.com
The zebrafish research community is celebrating! The zebrafish genome has recently been
sequenced, the Zebrafish Mutation Project (launched by the Wellcome Trust Sanger …
sequenced, the Zebrafish Mutation Project (launched by the Wellcome Trust Sanger …
The core promoter: At the heart of gene expression
YM Danino, D Even, D Ideses… - Biochimica et Biophysica …, 2015 - Elsevier
The identities of different cells and tissues in multicellular organisms are determined by
tightly controlled transcriptional programs that enable accurate gene expression. The …
tightly controlled transcriptional programs that enable accurate gene expression. The …
An atlas of active enhancers across human cell types and tissues
Enhancers control the correct temporal and cell-type-specific activation of gene expression
in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial …
in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial …
Synthetic promoter designs enabled by a comprehensive analysis of plant core promoters
Targeted engineering of plant gene expression holds great promise for ensuring food
security and for producing biopharmaceuticals in plants. However, this engineering requires …
security and for producing biopharmaceuticals in plants. However, this engineering requires …
A high-resolution mRNA expression time course of embryonic development in zebrafish
We have produced an mRNA expression time course of zebrafish development across 18
time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos …
time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos …
[HTML][HTML] Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements
Zebrafish, a popular organism for studying embryonic development and for modeling human
diseases, has so far lacked a systematic functional annotation program akin to those in other …
diseases, has so far lacked a systematic functional annotation program akin to those in other …
Quantitative high-speed imaging of entire developing embryos with simultaneous multiview light-sheet microscopy
Live imaging of large biological specimens is fundamentally limited by the short optical
penetration depth of light microscopes. To maximize physical coverage, we developed the …
penetration depth of light microscopes. To maximize physical coverage, we developed the …
Systematic analysis of intrinsic enhancer-promoter compatibility in the mouse genome
Gene expression is in part controlled by cis-regulatory elements (CREs) such as enhancers
and repressive elements. Anecdotal evidence has indicated that a CRE and a promoter …
and repressive elements. Anecdotal evidence has indicated that a CRE and a promoter …
Acoustofluidic rotational tweezing enables high-speed contactless morphological phenotyping of zebrafish larvae
Modern biomedical research and preclinical pharmaceutical development rely heavily on
the phenotyping of small vertebrate models for various diseases prior to human testing. In …
the phenotyping of small vertebrate models for various diseases prior to human testing. In …
High-throughput in vivo vertebrate screening
We demonstrate a high-throughput platform for cellular-resolution in vivo chemical and
genetic screens on zebrafish larvae. The system automatically loads zebrafish from …
genetic screens on zebrafish larvae. The system automatically loads zebrafish from …