Obsessive-compulsive disorder is a severe and disabling psychiatric disorder that presents
several challenges for neuroscience. Recent advances in its genetic and developmental …

Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling
disorder. The only established first-line treatments for OCD are exposure and response …

Though only a decade has elapsed since the default network (DN) was first defined as a
large‐scale brain system, recent years have brought great insight into the network's adaptive …

Microglia are phagocytic cells that infiltrate the brain during development and have a role in
the elimination of synapses during brain maturation. Changes in microglial morphology and …

Abstract Parkinson's disease (PD), the second most common age-associated
neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and …

Obsessive–compulsive disorder (OCD) is characterized by repetitive thoughts and
behaviours that are experienced as unwanted. Family and twin studies have demonstrated …

Emotion, memories and behaviour emerge from the coordinated activities of regions
connected by the limbic system. Here, we propose an update of the limbic model based on …

Corticostriatal projections are essential components of forebrain circuits and are widely
involved in motivated behaviour. These axonal projections are formed by two distinct …

Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex
human behaviors such as evaluation, affect regulation and reward-based decision-making …

Background Understanding the neural mechanisms of psychiatric disorders requires the use
of rodent models; however, frontal-striatal homologies between rodents and primates are …