The role of surfactant in lung disease and host defense against pulmonary infections

SH Han, RK Mallampalli - Annals of the American Thoracic Society, 2015 - atsjournals.org
Pulmonary surfactant is essential for life as it lines the alveoli to lower surface tension,
thereby preventing atelectasis during breathing. Surfactant is enriched with a relatively …

Surfactant protein D in respiratory and non-respiratory diseases

GL Sorensen - Frontiers in medicine, 2018 - frontiersin.org
Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …

Common and distinct clinical features in adult patients with anti-aminoacyl-tRNA synthetase antibodies: heterogeneity within the syndrome

Y Hamaguchi, M Fujimoto, T Matsushita, K Kaji… - PloS one, 2013 - journals.plos.org
Objective To identify similarities and differences in the clinical features of adult Japanese
patients with individual anti-aminoacyl-tRNA synthetase antibodies (anti-ARS Abs). Methods …

Pulmonary surfactant in health and human lung diseases: state of the art

M Griese - European Respiratory Journal, 1999 - Eur Respiratory Soc
Pulmonary surfactant is a complex and highly surface active material composed of lipids and
proteins which is found in the fluid lining the alveolar surface of the lungs. Surfactant …

Surfactant proteins A and D and pulmonary host defense

E Crouch, JR Wright - Annual review of physiology, 2001 - annualreviews.org
▪ Abstract The lung collectins, SP-A and SP-D, are important components of the innate
immune response to microbial challenge and participate in other aspects of immune and …

Comparative study of KL-6, surfactant protein-A, surfactant protein-D, and monocyte chemoattractant protein-1 as serum markers for interstitial lung diseases

H Ohnishi, A Yokoyama, K Kondo… - American journal of …, 2002 - atsjournals.org
KL-6, surfactant protein (SP)-A, SP-D, and monocyte chemoattractant protein-1 (MCP-1) are
reported to be sensitive markers for interstitial lung diseases (ILD). However, each marker …

Lung epithelium–specific proteins: characteristics and potential applications as markers

C Hermans, A Bernard - American journal of respiratory and critical …, 1999 - atsjournals.org
Conclusions The lung interfaces with the environment across a continuous and
heterogeneous epithelium. The proximal conducting airways are lined with a …

Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS

KE Greene, JR Wright, KP Steinberg… - American journal of …, 1999 - atsjournals.org
The goal of this study was to determine the changes that occur in surfactant-associated
proteins in bronchoalveolar lavage fluid (BAL) and serum of patients at risk for ARDS and …

[HTML][HTML] Comprehensive assessment of myositis-specific autoantibodies in polymyositis/dermatomyositis-associated interstitial lung disease

H Hozumi, T Fujisawa, R Nakashima, T Johkoh… - Respiratory …, 2016 - Elsevier
Abstract Objectives Myositis-specific autoantibodies (MSAs) are associated with clinical
phenotypes in polymyositis/dermatomyositis (PM/DM). No study has investigated the clinical …

Immunomodulatory functions of surfactant

JR Wright - Physiological reviews, 1997 - journals.physiology.org
The possibility that the lipoprotein complex of lung surfactant functions in pulmonary host
defense as well as lowering surface tension at the air-liquid interface has been the subject of …