[HTML][HTML] Inflammation in fear-and anxiety-based disorders: PTSD, GAD, and beyond

V Michopoulos, A Powers, CF Gillespie… - …, 2017 - nature.com
The study of inflammation in fear-and anxiety-based disorders has gained interest as
growing literature indicates that pro-inflammatory markers can directly modulate affective …

Understanding resilience: New approaches for preventing and treating PTSD

SR Horn, DS Charney, A Feder - Experimental neurology, 2016 - Elsevier
All individuals experience stressful life events, and up to 84% of the general population will
experience at least one potentially traumatic event. In some cases, acute or chronic …

[HTML][HTML] Animal models of PTSD: a challenge to be met

G Richter-Levin, O Stork, MV Schmidt - Molecular psychiatry, 2019 - nature.com
Recent years have seen increased interest in psychopathologies related to trauma
exposure. Specifically, there has been a growing awareness to posttraumatic stress disorder …

[HTML][HTML] The link between chronic stress and accelerated aging

YE Yegorov, AV Poznyak, NG Nikiforov, IA Sobenin… - Biomedicines, 2020 - mdpi.com
People exposed to chronic stress age rapidly. The telomeres in their cells of all types
shorten faster. Inflammation is another important feature of stress that, along with aging …

Gene expression in the primate orbitofrontal cortex related to anxious temperament

MM Kenwood, T Souaiaia, R Kovner… - Proceedings of the …, 2023 - National Acad Sciences
Anxiety disorders are among the most prevalent psychiatric disorders, causing significant
suffering and disability. Relative to other psychiatric disorders, anxiety disorders tend to …

Glucocorticoids and hippocampal structure and function in PTSD

PR Szeszko, A Lehrner, R Yehuda - Harvard review of psychiatry, 2018 - journals.lww.com
This review examines the putative link between glucocorticoid and hippocampal
abnormalities in posttraumatic stress disorder (PTSD). Increased glucocorticoid receptor …

New translational perspectives for blood-based biomarkers of PTSD: from glucocorticoid to immune mediators of stress susceptibility

NP Daskalakis, H Cohen, CM Nievergelt… - Experimental …, 2016 - Elsevier
Although biological systems have evolved to promote stress-resilience, there is variation in
stress-responses. Understanding the biological basis of such individual differences has …

SKA2 methylation is associated with decreased prefrontal cortical thickness and greater PTSD severity among trauma-exposed veterans

N Sadeh, JM Spielberg, MW Logue, EJ Wolf… - Molecular …, 2016 - nature.com
Methylation of the SKA2 (spindle and kinetochore-associated complex subunit 2) gene has
recently been identified as a promising biomarker of suicide risk. Based on this finding, we …

Neuroactive steroids and PTSD treatment

AM Rasmusson, CE Marx, SL Pineles, A Locci… - Neuroscience …, 2017 - Elsevier
This review highlights early efforts to translate pre-clinical and clinical findings regarding the
role of neuroactive steroids in stress adaptation and PTSD into new therapeutics for PTSD …

Epigenetic effects of PTSD remediation in veterans using clinical emotional freedom techniques: a randomized controlled pilot study

D Church, G Yount, K Rachlin, L Fox… - American Journal of …, 2018 - journals.sagepub.com
Purpose: To assess the feasibility of measuring changes in gene expression associated with
post-traumatic stress disorder (PTSD) treatment using emotional freedom techniques (EFT) …