The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

[HTML][HTML] Gut microbiome: profound implications for diet and disease

RD Hills, BA Pontefract, HR Mishcon, CA Black… - Nutrients, 2019 - mdpi.com
The gut microbiome plays an important role in human health and influences the
development of chronic diseases ranging from metabolic disease to gastrointestinal …

Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery

J Zhou, M Li, Q Chen, X Li, L Chen, Z Dong… - Nature …, 2022 - nature.com
Reactive oxygen species (ROS) play vital roles in intestinal inflammation. Therefore,
eliminating ROS in the inflammatory site by antioxidant enzymes such as catalase and …

[HTML][HTML] Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer

W Fong, Q Li, J Yu - Oncogene, 2020 - nature.com
Research about the role of gut microbiome in colorectal cancer (CRC) is a newly emerging
field of study. Gut microbiota modulation, with the aim to reverse established microbial …

Genetically stable CRISPR-based kill switches for engineered microbes

AG Rottinghaus, A Ferreiro, SRS Fishbein… - Nature …, 2022 - nature.com
Microbial biocontainment is an essential goal for engineering safe, next-generation living
therapeutics. However, the genetic stability of biocontainment circuits, including kill switches …

Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study

MK Puurunen, J Vockley, SL Searle, SJ Sacharow… - Nature …, 2021 - nature.com
Phenylketonuria (PKU) is a rare disease caused by biallelic mutations in the PAH gene that
result in an inability to convert phenylalanine (Phe) to tyrosine, elevated blood Phe levels …

Probiotics and the microbiota-gut-brain axis: focus on psychiatry

S Mörkl, MI Butler, A Holl, JF Cryan, TG Dinan - Current nutrition reports, 2020 - Springer
Abstract Purpose of Review Probiotics are living bacteria, which when ingested in adequate
amounts, confer health benefits. Gut microbes are suggested to play a role in many …

Precise quantification of bacterial strains after fecal microbiota transplantation delineates long-term engraftment and explains outcomes

V Aggarwala, I Mogno, Z Li, C Yang, GJ Britton… - Nature …, 2021 - nature.com
Fecal microbiota transplantation (FMT) has been successfully applied to treat recurrent
Clostridium difficile infection in humans, but a precise method to measure which bacterial …

Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes

BJ Russell, SD Brown, N Siguenza, I Mai, AR Saran… - Cell, 2022 - cell.com
Live bacterial therapeutics (LBTs) could reverse diseases by engrafting in the gut and
providing persistent beneficial functions in the host. However, attempts to functionally …

Fecal microbiota transplantation in disease therapy

H Antushevich - Clinica Chimica Acta, 2020 - Elsevier
Fecal microbiota transplantation (FMT) is the introduction (transplantation) of gut microbiota
obtained from the faeces of a healthy donor into the patient's gastrointestinal tract. Most …