[HTML][HTML] GLP-1 receptor agonists: beyond their pancreatic effects

X Zhao, M Wang, Z Wen, Z Lu, L Cui, C Fu… - Frontiers in …, 2021 - frontiersin.org
Glucagon like peptide-1 (GLP-1) is an incretin secretory molecule. GLP-1 receptor agonists
(GLP-1RAs) are widely used in the treatment of type 2 diabetes (T2DM) due to their …

Safety of semaglutide

MM Smits, DH Van Raalte - Frontiers in endocrinology, 2021 - frontiersin.org
The glucagon-like peptide-1 receptor agonist (GLP-1RA) semaglutide is the most recently
approved agent of this drug class, and the only GLP-1RA currently available as both …

Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis

MA Bethel, RA Patel, P Merrill… - The lancet Diabetes & …, 2018 - thelancet.com
Summary Background Glucagon-like peptide-1 (GLP-1) receptor agonists are effective
glucose-lowering drugs. Findings from cardiovascular outcome trials showed cardiovascular …

Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation

BA McLean, CK Wong, JE Campbell… - Endocrine …, 2021 - academic.oup.com
Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …

GLP-1 receptor agonist-associated tumor adverse events: A real-world study from 2004 to 2021 based on FAERS

Z Yang, Y Lv, M Yu, M Mei, L Xiang, S Zhao… - Frontiers in …, 2022 - frontiersin.org
Background: GLP-1 receptor agonists (GLP-1RA) have demonstrated cardiovascular
benefits, but the relationship between GLP-1RA and tumors is controversial. Recently …

Use of GLP-1 receptor agonists and occurrence of thyroid disorders: a meta-analysis of randomized controlled trials

W Hu, R Song, R Cheng, C Liu, R Guo… - Frontiers in …, 2022 - frontiersin.org
The association between glucagon-like peptide-1 (GLP-1) receptor agonists and the risk of
various kinds of thyroid disorders remains uncertain. We aimed to evaluate the relationship …

A critical analysis of the clinical use of incretin-based therapies: are the GLP-1 therapies safe?

PC Butler, M Elashoff, R Elashoff, EAM Gale - Diabetes care, 2013 - Am Diabetes Assoc
There is no question that incretin-based glucose-lowering medications have proven to be
effective glucose-lowering agents. Glucagon-like peptide 1 (GLP-1) receptor agonists …

Glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1: incretin actions beyond the pancreas

Y Seino, D Yabe - Journal of diabetes investigation, 2013 - Wiley Online Library
Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1)
are the two primary incretin hormones secreted from the intestine on ingestion of various …

Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls

DJ Drucker - Diabetes, 2013 - Am Diabetes Assoc
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)
are incretin hormones that control the secretion of insulin, glucagon, and somatostatin to …

Risk of thyroid cancer associated with glucagon‐like peptide‐1 receptor agonists and dipeptidyl peptidase‐4 inhibitors in patients with type 2 diabetes: a population …

S Bea, H Son, JH Bae, SW Cho… - Diabetes, Obesity and …, 2024 - Wiley Online Library
Aims To determine the potential association between the use of either glucagon‐like peptide‐
1 receptor agonists (GLP‐1RAs) or dipeptidyl peptidase‐4 (DPP‐4) inhibitors, and the risk of …