Epstein-Barr virus: Biology and clinical disease
B Damania, SC Kenney, N Raab-Traub - Cell, 2022 - cell.com
Epstein-Barr virus (EBV) is a ubiquitous, oncogenic virus that is associated with a number of
different human malignancies as well as autoimmune disorders. The expression of EBV viral …
different human malignancies as well as autoimmune disorders. The expression of EBV viral …
Molecular mechanisms of viral oncogenesis in humans
NA Krump, J You - Nature Reviews Microbiology, 2018 - nature.com
Viral infection is a major contributor to the global cancer burden. Recent advances have
revealed that seven known oncogenic viruses promote tumorigenesis through shared host …
revealed that seven known oncogenic viruses promote tumorigenesis through shared host …
Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism
Ferroptosis is a specialized iron-dependent cell death that is associated with lethal lipid
peroxidation. Modulation of ferroptosis may have therapeutic potential since it has been …
peroxidation. Modulation of ferroptosis may have therapeutic potential since it has been …
[HTML][HTML] Epstein–Barr virus latent genes
MS Kang, E Kieff - Experimental & molecular medicine, 2015 - nature.com
Abstract Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …
[HTML][HTML] Nonproteolytic functions of ubiquitin in cell signaling
The small protein ubiquitin is a central regulator of a cell's life and death. Ubiquitin is best
known for targeting protein destruction by the 26S proteasome. In the past few years …
known for targeting protein destruction by the 26S proteasome. In the past few years …
CD63 regulates epstein-barr virus LMP1 exosomal packaging, enhancement of vesicle production, and noncanonical NF-κB signaling
SN Hurwitz, D Nkosi, MM Conlon, SB York… - Journal of …, 2017 - Am Soc Microbiol
ABSTRACT Latent membrane protein 1 (LMP1) is an Epstein-Barr virus (EBV)-encoded
oncoprotein that is packaged into small extracellular vesicles (EVs) called exosomes …
oncoprotein that is packaged into small extracellular vesicles (EVs) called exosomes …
miR-146a Suppresses Invasion of Pancreatic Cancer Cells
Y Li, TG VandenBoom, Z Wang, D Kong, S Ali… - Cancer research, 2010 - AACR
The aggressive course of pancreatic cancer is believed to reflect its unusually invasive and
metastatic nature, which is associated with epidermal growth factor receptor (EGFR) …
metastatic nature, which is associated with epidermal growth factor receptor (EGFR) …
Current insights into the regulation of programmed cell death by NF-κB
J Dutta, Y Fan, N Gupta, G Fan, C Gelinas - Oncogene, 2006 - nature.com
The nuclear factor-kappaB (NF-κB) transcription factors have emerged as major regulators
of programmed cell death (PCD) whether via apoptosis or necrosis. In this context, NF-κB's …
of programmed cell death (PCD) whether via apoptosis or necrosis. In this context, NF-κB's …
[HTML][HTML] TNF receptor associated factor 2 (TRAF2) signaling in cancer
D Siegmund, J Wagner, H Wajant - Cancers, 2022 - mdpi.com
Simple Summary Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) is an
intracellular adapter protein with E3 ligase activity, which interacts with a plethora of other …
intracellular adapter protein with E3 ligase activity, which interacts with a plethora of other …
LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF‐κB activation
FJ Verweij, MAJ Van Eijndhoven, ES Hopmans… - The EMBO …, 2011 - embopress.org
The ubiquitous Epstein Barr virus (EBV) exploits human B‐cell development to establish a
persistent infection in∼ 90% of the world population. Constitutive activation of NF‐κB by the …
persistent infection in∼ 90% of the world population. Constitutive activation of NF‐κB by the …