New approaches to the prognostic assessment of breast cancer have come from molecular
profiling studies. A major feature of this work has been to emphasise the importance of …

Immunohistochemistry (IHC) is still widely used as a morphology-based assay for in situ
analysis of target proteins as specific tumor antigens. However, as a very heterogeneous …

Most estrogen receptor α (ER)-positive breast cancers initially respond to antiestrogens, but
many eventually become estrogen-independent and recur. We identified an estrogen …

MicroRNAs (miRNAs) are short noncoding regulatory RNA molecules that modulate protein
expression by inhibiting mRNA translation or promoting mRNA degradation. However, little …

1, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3 or calcitriol], the hormonally active vitamin D
metabolite, exhibits anticancer actions in models of breast cancer and prostate cancer …

Aims: Counting mitotic figures is considered to be a reliable prognosticator, but evaluation of
Ki67 immunohistochemistry has become more popular in evaluating proliferation. Our …

Background E-cadherin and vimentin are regarded as major conventional canonical
markers of the epithelial–mesenchymal transition. It is commonly assumed that E-cadherin is …

The development of simple, cost-effective, and advanced multifunctional technology is the
need of the hour to combat cancer as well as bacterial infections. There have been reports of …

Despite great strides toward diagnosis and therapy, breast cancer remains a most
threatening disease in its incidence, morbidity and mortality; therefore, additional knowledge …

Purpose: Kruppel-like factor (KLF5) is a cell growth mediator in various epithelial cells.
Higher KLF5 increases cell growth rate and leads to transformed phenotypes. Because …