Even when split into several chromosomes, DNA molecules that make up our genome are
too long to fit into the cell nuclei unless massively folded. Such folding must accommodate …

High-resolution Micro-C maps identified a specialized class of regulatory DNAs termed
'tethering elements'(TEs) in Drosophila. These 300–500-bp elements facilitate specific long …

Chromatin loops between gene pairs have been observed in diverse contexts in both flies
and vertebrates. Combining high-resolution Capture-C, DNA fluorescence in situ …

Two different models have been proposed to explain how the endpoints of chromatin looped
domains ('TADs') in eukaryotic chromosomes are determined. In the first, a cohesin complex …

The chromosomes in multicellular eukaryotes are organized into a series of topologically
independent loops called TADs. In flies, TADs are formed by physical interactions between …

Genome organization can regulate gene expression and promote cell fate transitions. The
differentiation of germline stem cells (GSCs) to oocytes in Drosophila involves changes in …

Enhancers are noncoding regulatory elements that instruct spatial and temporal specificity of
gene transcription in response to a variety of intrinsic and extrinsic signals during …

Highlights•Chromatin regulators orchestrate the pace and order of gene expression
programs in differentiating neurons.•Disease-associated mutations in chromatin regulators …

It is well established that neutrophils adopt malleable polymorphonuclear shapes to migrate
through narrow interstitial tissue spaces,–. However, how polymorphonuclear structures are …

Partitioning of repressive from actively transcribed chromatin in mammalian cells fosters cell-
type-specific gene expression patterns. While this partitioning is reconstructed during …