Roughly one quarter of all genes code for integral membrane proteins that are inserted into
the plasma membrane of prokaryotes or the endoplasmic reticulum membrane of …

Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are
considered as specialized immune cells that can be genetically modified to obtain capable …

The rapid detection of microbial agents is essential for the effective initiation of host defence
mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger …

The description of the non-equilibrium dynamics of isolated quantum many-body systems
within the framework of statistical mechanics is a fundamental open question. Conventional …

As our understanding of the cell interior has grown, we have come to appreciate that most
cellular operations are localized, that is, they occur at discrete and identifiable locations or …

Cotranslational protein translocation is a universally conserved process for secretory and
membrane protein biosynthesis. Nascent polypeptides emerging from a translating …

Mutations in C9ORF72 are the most common cause of familial amyotrophic lateral sclerosis
(ALS). Here, through a combination of RNA-Seq and electrophysiological studies on …

Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many
chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate …

Proteases enzymatically hydrolyze peptide bonds in substrate proteins, resulting in a
widespread, irreversible posttranslational modification of the protein's structure and …

In recent decades, peptides, which can possess high potency, excellent selectivity, and low
toxicity, have emerged as promising therapeutics for cancer applications. Combined with an …