Therapeutic strategies to overcome taxane resistance in cancer
One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …
emergence of multidrug resistance (MDR). Numerous studies have been published …
Application of mesoporous silica nanoparticles in cancer therapy and delivery of repurposed anthelmintics for cancer therapy
This review focuses on the biomedical application of mesoporous silica nanoparticles
(MSNs), mainly focusing on the therapeutic application of MSNs for cancer treatment and …
(MSNs), mainly focusing on the therapeutic application of MSNs for cancer treatment and …
Transposon-triggered innate immune response confers cancer resistance to the blind mole rat
Blind mole rats (BMRs) are small rodents, characterized by an exceptionally long lifespan (>
21 years) and resistance to both spontaneous and induced tumorigenesis. Here we report …
21 years) and resistance to both spontaneous and induced tumorigenesis. Here we report …
Drug repurposing for cancer therapy
Y Xia, M Sun, H Huang, WL Jin - Signal Transduction and Targeted …, 2024 - nature.com
Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …
health. Despite significant advances in surgical, radiotherapeutic and immunological …
Disulfiram: mechanisms, applications, and challenges
J Lanz, N Biniaz-Harris, M Kuvaldina, S Jain, K Lewis… - Antibiotics, 2023 - mdpi.com
Background: Since disulfiram's discovery in the 1940s and its FDA approval for alcohol use
disorder, other indications have been investigated. This review describes potential clinical …
disorder, other indications have been investigated. This review describes potential clinical …
Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells
YH Chen, SF Yang, CK Yang… - Molecular …, 2021 - spandidos-publications.com
Human cervical cancer is the fourth most common malignancy among women worldwide,
and it is expected to result in 460,000 deaths per year by 2040. Moreover, patients with …
and it is expected to result in 460,000 deaths per year by 2040. Moreover, patients with …
Repurposing old drugs to fight multidrug resistant cancers
Overcoming multidrug resistance represents a major challenge for cancer treatment. In the
search for new chemotherapeutics to treat malignant diseases, drug repurposing gained a …
search for new chemotherapeutics to treat malignant diseases, drug repurposing gained a …
Emerging perspectives on the antiparasitic mebendazole as a repurposed drug for the treatment of brain cancers
D Meco, G Attinà, S Mastrangelo, P Navarra… - International Journal of …, 2023 - mdpi.com
Repurposing approved non-antitumor drugs is a promising and affordable strategy in drug
discovery to identify new therapeutic uses different from the original medical indication that …
discovery to identify new therapeutic uses different from the original medical indication that …
Microglia: a double-edged sword in intracerebral hemorrhage from basic mechanisms to clinical research
Microglia are the resident immune cells of the central nervous system (CNS). It is well
established that microglia are activated and polarized to acquire different inflammatory …
established that microglia are activated and polarized to acquire different inflammatory …
Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects
Cancer poses a significant global health challenge, with predictions of increasing
prevalence in the coming years due to limited prevention, late diagnosis, and inadequate …
prevalence in the coming years due to limited prevention, late diagnosis, and inadequate …