A review of cancer immunotherapy: from the past, to the present, to the future
K Esfahani, L Roudaia, N Buhlaiga, SV Del Rincon… - Current …, 2020 - mdpi.com
A review of cancer immunotherapy: from the past, to the present, to the future Page 1 S87
Current Oncology, Vol. 27, Supp. 2, April 2020 © 2020 Multimed Inc. REVIEW ARTICLE A …
Current Oncology, Vol. 27, Supp. 2, April 2020 © 2020 Multimed Inc. REVIEW ARTICLE A …
Cancer plasticity: the role of mRNA translation
LJ Lee, D Papadopoli, M Jewer, S Del Rincon… - Trends in cancer, 2021 - cell.com
Tumor progression is associated with dedifferentiated histopathologies concomitant with
cancer cell survival within a changing, and often hostile, tumor microenvironment. These …
cancer cell survival within a changing, and often hostile, tumor microenvironment. These …
The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment
M Bartish, MJ Abraham, C Gonçalves… - Nature Reviews …, 2023 - nature.com
Cells can rapidly adjust their proteomes in dynamic environments by regulating mRNA
translation. There is mounting evidence that dysregulation of mRNA translation supports the …
translation. There is mounting evidence that dysregulation of mRNA translation supports the …
[HTML][HTML] Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses
F Huang, C Gonçalves, M Bartish… - The Journal of …, 2024 - Am Soc Clin Investig
Melanomas commonly undergo a phenotype switch, from a proliferative to an invasive state.
Such tumor cell plasticity contributes to immunotherapy resistance; however, the …
Such tumor cell plasticity contributes to immunotherapy resistance; however, the …
Progress in developing MNK inhibitors
The MNKs (mitogen-activated protein kinase-interacting protein kinases) phosphorylate
eIF4E (eukaryotic initiation factor 4 E) at serine 209; eIF4E plays an important role in the …
eIF4E (eukaryotic initiation factor 4 E) at serine 209; eIF4E plays an important role in the …
MAPK-interacting kinase 1 regulates platelet production, activation, and thrombosis
BK Manne, RA Campbell, S Bhatlekar… - Blood, The Journal …, 2022 - ashpublications.org
The MAPK-interacting kinase (Mnk) family includes Mnk1 and Mnk2, which are
phosphorylated and activated in response to extracellular stimuli. Mnk1 contributes to …
phosphorylated and activated in response to extracellular stimuli. Mnk1 contributes to …
The MNK1/2–eIF4E axis supports immune suppression and metastasis in postpartum breast cancer
Breast cancer diagnosed within 10 years following childbirth is defined as postpartum breast
cancer (PPBC) and is highly metastatic. Interactions between immune cells and other …
cancer (PPBC) and is highly metastatic. Interactions between immune cells and other …
Melanoma plasticity: promoter of metastasis and resistance to therapy
F Huang, F Santinon, RE Flores González… - Frontiers in …, 2021 - frontiersin.org
Melanoma is the deadliest form of skin cancer. Although targeted therapies and
immunotherapies have revolutionized the treatment of metastatic melanoma, most patients …
immunotherapies have revolutionized the treatment of metastatic melanoma, most patients …
[HTML][HTML] Phosphorylation of eIF4E in the stroma drives the production and spatial organisation of collagen type I in the mammary gland
The extracellular matrix (ECM) plays critical roles in breast cancer development. Whether
ECM composition is regulated by the phosphorylation of eIF4E on serine 209, an event …
ECM composition is regulated by the phosphorylation of eIF4E on serine 209, an event …
Deeping in the role of the MAP-kinases interacting kinases (MNKs) in cancer
C Pinto-Díez, R Ferreras-Martín… - International Journal of …, 2020 - mdpi.com
The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are involved in
oncogenic transformation and can promote metastasis and tumor progression. In human …
oncogenic transformation and can promote metastasis and tumor progression. In human …