Mammalian Na+/Ca2+ exchangers are members of three branches of a much larger family
of transport proteins [the CaCA (Ca2+/cation antiporter) superfamily] whose main role is to …

All eukaryotic cells import Ca2+ through a number of variously gated plasma membrane
channels. Once inside cells, Ca2+ transmits information to a large number of (enzyme) …

Migraine is a debilitating neurological disorder affecting around one in seven people
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …

Cation/Ca2+ exchangers are an essential component of Ca2+ signaling pathways and
function to transport cytosolic Ca2+ across membranes against its electrochemical gradient …

The spermatozoon is specialized for a single vital role in fertilization. Past studies show that
Ca2+ signals produced by the opening of plasma membrane entry channels initiate several …

Introduction 3.[Ca2+] i regulation in mammalian sperm: the sperm's Ca2+-signalling toolkit
3.1 Ca2+ handling at the plasma membrane–Ca2+ channels and pumps 3.2 Intracellular …

Ca2+ is a ubiquitous intracellular messenger which encodes information by temporal and
spatial patterns of concentration. In spermatozoa, several key functions, including acrosome …

Bioinformatic and molecular cloning tools were used to identify and isolate cDNA clones
from mouse and human tissues that encode the sixth member of the K+-dependent Na+/Ca …

Abstract Na+/Ca 2+-K+ exchange (NCKX) was first discovered in the outer segments of
vertebrate rod photoreceptors (ROS), where it is the only mechanism for extruding the Ca 2+ …

We report here the identification and characterization of a fourth member of the potassium-
dependent sodium-calcium exchanger gene family, NCKX4 (gene SLC24A4), which …