[HTML][HTML] Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of …
Platelets are small anucleate cells generated from megakaryocytes in the bone marrow.
Although platelet generation, maturation, and clearance are still not fully understood …
Although platelet generation, maturation, and clearance are still not fully understood …
Platelet mechanotransduction
The vasculature is a dynamic environment in which blood platelets constantly survey the
endothelium for sites of vessel damage. The formation of a mechanically coherent …
endothelium for sites of vessel damage. The formation of a mechanically coherent …
Quercitrin inhibits platelet activation in arterial thrombosis
Background The ingestion of flavonoids has been reported to be associated with reduced
cardiovascular disease risk. Quercitrin is a common flavonoid in nature, and it exhibits …
cardiovascular disease risk. Quercitrin is a common flavonoid in nature, and it exhibits …
[HTML][HTML] Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα
Background Platelets are essential for maintaining haemostasis and play a key role in the
pathogenesis of cardiovascular disease. Upon ligation of platelet receptors through …
pathogenesis of cardiovascular disease. Upon ligation of platelet receptors through …
Asebogenin suppresses thrombus formation via inhibition of Syk phosphorylation
L Li, X Xu, K Lv, G Zheng, H Wang… - British journal of …, 2023 - Wiley Online Library
Abstract Background and Purpose Thrombosis is a major cause of morbidity and mortality
worldwide. Platelet activation by exposed collagen through glycoprotein VI (GPVI) and …
worldwide. Platelet activation by exposed collagen through glycoprotein VI (GPVI) and …
Focal adhesion kinases in platelet function and thrombosis
The focal adhesion kinase family includes 2 homolog members, FAK and Pyk2 (proline-rich
tyrosine kinase 2), primarily known for their roles in nucleated cells as regulators of …
tyrosine kinase 2), primarily known for their roles in nucleated cells as regulators of …
Intraplatelet reactive oxygen species (ROS) correlate with the shedding of adhesive receptors, microvesiculation and platelet adhesion to collagen during storage …
M Ghasemzadeh, E Hosseini, ZO Roudsari… - Thrombosis …, 2018 - Elsevier
Platelets storage lesion is mainly orchestrated by platelet activating signals during storage.
Reactive oxygen species (ROS) are being considered as important signaling molecules …
Reactive oxygen species (ROS) are being considered as important signaling molecules …
A comprehensive tyrosine phosphoproteomic analysis reveals novel components of the platelet CLEC-2 signaling cascade
I Izquierdo, MN Barrachina… - Thrombosis and …, 2020 - thieme-connect.com
C-type lectin-like receptor 2 (CLEC-2) plays a crucial role in different platelet-related
physiological and pathological processes. It signals through a tyrosine kinase-mediated …
physiological and pathological processes. It signals through a tyrosine kinase-mediated …
Blood compatibility of magnesium and its alloys
F Feyerabend, HP Wendel, B Mihailova, S Heidrich… - Acta biomaterialia, 2015 - Elsevier
Rationale Blood compatibility analysis in the field of biomaterials is a highly controversial
topic. Especially for degradable materials like magnesium and its alloys no established test …
topic. Especially for degradable materials like magnesium and its alloys no established test …
[HTML][HTML] Small molecule targeting the Rac1‐NOX2 interaction prevents collagen‐related peptide and thrombin‐induced reactive oxygen species generation and …
Essentials• Reactive oxygen species (ROS) generation by NOX2 plays a critical role in
platelet activation.• Rac1 regulation of NOX2 is important for ROS generation.• Small …
platelet activation.• Rac1 regulation of NOX2 is important for ROS generation.• Small …