G-protein-coupled receptors (GPCRs) represent by far the largest class of targets for modern
drugs. Virtually all therapeutics that are directed towards GPCRs have been designed using …

The G-protein coupled receptors form a large and diverse multi-gene superfamily with many
important physiological functions. As such, they have become important targets in …

The availability of a high-resolution structure of rhodopsin now allows us to reconsider
research attempts to understand structure-function relationships in other G protein-coupled …

G-protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors in the human genome that respond to a plethora of signals, including …

Evidence for heterodimerization has recently been provided for dopamine D 1 and
adenosine A 1 receptors as well as for dopamine D 2 and somatostatin SSTR 5 receptors. In …

3, 5-Diacyl-2, 4-dialkyl-6-phenylpyridine derivatives have been found to be selective
antagonists at both human and rat A3 adenosine receptors (Li et al. J. Med. Chem. 1998, 41 …

Evidence has been obtained for adenosine/dopamine interactions in the central nervous
system. There exists an anatomical basis for the existence of functional interactions between …

Protein-protein interactions are involved in the regulation of a large number of biological
processes. It is well established that a variety of cell surface receptors interact with each …

In this study, we examined the mechanisms of intermolecular interaction involved in D2
dopamine receptor dimer formation to develop an understanding of the quaternary structure …

Numerous mutant G protein-coupled receptors with diminished or no function have been
described that are naturally occurring or that are the product of gene manipulation. It has …