The dynamic lung microbiome in health and disease

JG Natalini, S Singh, LN Segal - Nature Reviews Microbiology, 2023 - nature.com
New methods and technologies within the field of lung biology are beginning to shed new
light into the microbial world of the respiratory tract. Long considered to be a sterile …

Primary prevention of asthma: from risk and protective factors to targeted strategies for prevention

E von Mutius, HH Smits - The Lancet, 2020 - thelancet.com
Asthma is a complex disease that often starts in childhood. Genomic and environmental
factors as well as aberrant immune maturation early in life can contribute to the onset of …

The infant gut virome is associated with preschool asthma risk independently of bacteria

C Leal Rodríguez, SA Shah, MA Rasmussen… - Nature Medicine, 2024 - nature.com
Bacteriophage (also known as phage) communities that inhabit the gut have a major effect
on the structure and functioning of bacterial populations, but their roles and association with …

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

H Breiteneder, YQ Peng, I Agache, Z Diamant… - Allergy, 2020 - Wiley Online Library
Modern health care requires a proactive and individualized response to diseases,
combining precision diagnosis and personalized treatment. Accordingly, the approach to …

Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

J Stokholm, J Thorsen, MJ Blaser… - Science translational …, 2020 - science.org
There have been reports of associations between cesarean section delivery and the risk of
childhood asthma, potentially mediated through changes in the gut microbiota. We followed …

Early-life respiratory infections and developmental immunity determine lifelong lung health

CM Lloyd, S Saglani - Nature Immunology, 2023 - nature.com
Respiratory infections are common in infants and young children. However, the immune
system develops and matures as the child grows, thus the effects of infection during this time …

Early life microbiota and respiratory tract infections

WAA de Steenhuijsen Piters, J Binkowska, D Bogaert - Cell Host & Microbe, 2020 - cell.com
Over the last decade, it has become clear that respiratory and intestinal tract microbiota are
related to pathogenesis of respiratory tract infections (RTIs). Host and environmental factors …

Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk

HHF Tang, A Lang, SM Teo, LM Judd… - Journal of Allergy and …, 2021 - Elsevier
Background Studies indicate that the nasal microbiome may correlate strongly with the
presence or future risk of childhood asthma. Objectives In this study, we tested whether …

Urbanized microbiota in infants, immune constitution, and later risk of atopic diseases

J Lehtimäki, J Thorsen, MA Rasmussen… - Journal of Allergy and …, 2021 - Elsevier
Background Urbanization is linked with an increased burden of asthma and atopic traits. A
putative mechanism is insufficient exposure to beneficial microbes early in life, leading to …

Microbiome and asthma: microbial dysbiosis and the origins, phenotypes, persistence, and severity of asthma

J Valverde-Molina, L García-Marcos - Nutrients, 2023 - mdpi.com
The importance of the microbiome, and of the gut-lung axis in the origin and persistence of
asthma, is an ongoing field of investigation. The process of microbial colonisation in the first …