The gastrointestinal tract has the important task of absorbing nutrients, a complex process
that requires an intact barrier allowing the passage of nutrients but that simultaneously …

Highlights•Intraperitoneal Shigella infection is often used but lacks physiological
relevance.•The zebrafish larvae model is best for imaging studies.•The streptomycin-Nlrc4 …

Bacteria of the genus Shigella cause shigellosis, a severe gastrointestinal disease driven by
bacterial colonization of colonic intestinal epithelial cells. Vertebrates have evolved …

Candida albicans stably colonizes humans but is the leading cause of hospital-acquired
fungemia. Traditionally, masking immunogenic moieties has been viewed as a tactic for …

Multiple eukaryotic cell processes are modulated by calcium ions (Ca 2+). As such, Ca 2+ is
emerging as a crucial regulator of innate immunity in multicellular organisms. In particular …

Shigella spp. cause hundreds of millions of intestinal infections each year. They target the
mucosa of the human colon and are an important model of intracellular bacterial …

Type III interferon, or interferon lambda (IFNλ), was discovered 20 years ago and has been
studied primarily for its role in combatting viral infections. However, it is also induced in …

The major function of the mammalian immune system is to prevent and control infections
caused by enteropathogens that collectively have altered human destiny. In fact, as the …

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multifactorial
disease that causes increasing morbidity worldwide, and many individuals with ME/CFS …

Type I interferons (IFNs) are consequential cytokines in antibacterial defense. Whether and
how bacterial pathogens inhibit innate immune receptor-driven type I IFN expression …