New insights into understanding obesity: from measures to mechanisms

NJ Timpson, KH Wade, ML Smith… - BMJ …, 2024 - bmjmedicine.bmj.com
Associations between obesity and health are unequivocal and coupled with a substantial
body of evidence suggesting that associations are likely causal. These associations and the …

Adiposity, metabolites and endometrial cancer risk: Mendelian randomization and Observational analyses

MA Lee, VY Tan, D Pournaras, S Wang, L Dossus… - medRxiv, 2024 - medrxiv.org
Introduction Increased and excess adiposity is associated with increased risk of endometrial
cancer (EC) and both of these are associated with circulating metabolite profiles. However …

A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator

MA Lee, CA Hatcher, E Hazelwood, LJ Goudswaard… - medRxiv, 2024 - medrxiv.org
Adiposity is an established risk factor for colorectal cancer (CRC). However, the pathways
underlying this relationship, and specifically the role of the circulating proteome, is unclear …