Antimicrobial peptides (AMPs), or host defense peptides, are small cationic or amphipathic
molecules produced by prokaryotic and eukaryotic organisms that play a key role in the …

Antibiotic resistance is one of the biggest challenges for the clinical sector and industry,
environment and societal development. One of the most important pathogens responsible …

The rise in antibiotic-resistant strains of clinically important pathogens is a major threat to
global health. The World Health Organization (WHO) has recognized the urgent need to …

Endocytosis and endosome dynamics are controlled by proteins of the small GTPase Rab
family. Besides possible recycling routes to the plasma membrane and various organelles …

Cell-penetrating peptides (CPPs) are short (< 30 amino acids), generally cationic, peptides
that deliver diverse cargos into cells. CPPs access the cytosol either by direct translocation …

Cell-penetrating peptides (CPPs) allow intracellular delivery of bioactive cargo molecules.
The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based …

Bacterial resistance to antimicrobial drugs is one of the biggest threats to human health and
novel drugs, and strategies are needed to obviate this resistance crisis. An innovative …

Preclinical mouse models are critical for understanding the pathophysiological response to
infections and developing treatment strategies for sepsis. In keeping with ethical values …

TAT-RasGAP317–326 is a cell-penetrating peptide-based construct with anticancer and
antimicrobial activities. This peptide kills a subset of cancer cells in a manner that does not …

Objectives Biofilms are structured aggregates of bacteria embedded in a self-produced
matrix that develop in diverse ecological niches. Pathogenic bacteria can form biofilms on …