THE manufacture of predefined specific antibodies by means of permanent tissue culture
cell lines is of general interest. There are at present a considerable number of permanent …

Publisher Summary The immunoglobulins are a large family of structurally related proteins
secreted by plasma cells. Plasma cells are normally differentiated so that each cell is usually …

Nonenzymatic intramolecular reactions can result in the deamidation, isomerization, and
racemization of protein and peptide asparaginyl and aspartyl residues via succinimide …

Adeno-associated viruses (AAV) are ubiquitous in the human population (> 90% of adults
are seropositive) but have never been implicated as the cause of any disease. They were …

One mechanism for the spontaneous degradation of polypeptides is the intramolecular
attack of the peptide bond nitrogen on the side chain carbonyl carbon atom of aspartic acid …

IMMUNOGLOBULIN light chains are synthesized in heterologous cell-free systems from
reticulocytes1 and Krebs II ascites cells2, and in reconstituted homologous systems from …

Hemostasis and thrombosis (blood clotting) involve fibrinogen binding to integrin αIIbβ3 on
platelets, resulting in platelet aggregation. αvβ3 binds fibrinogen via an Arg-Asp-Gly (RGD) …

The ability of an organism to cope with foreign substances (antigens) depends in part on its
capacity to synthesize antibodies (immunoglobulins) of the proper binding specificity to …

α‐Thrombin cleavage of 30 polypeptide hormones and their derivatives were analysed by
quantitative aminoterminal analysis. The polypeptides included secretin, vasoactive …

The crystal structure of the Fab of McPC603, a phosphocholine-binding mouse myeloma
protein, has been refined at 2.7 Å resolution by a combination of restrained least-squares …