The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …

A large population of neural stem/precursor cells (NSCs) persists in the ventricular–
subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs …

Congenital hydrocephalus (CH), characterized by enlarged brain ventricles, is considered a
disease of excessive cerebrospinal fluid (CSF) accumulation and thereby treated with …

Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …

The hedgehog (HH) pathway is well known for its mitogenic and morphogenic functions
during development, and HH signaling continues in discrete populations of cells within …

Understanding the cell–cell interactions that control CNS development and function has
long been limited by the lack of methods to cleanly separate neural cell types. Here we …

Activation of Notch signaling induces the expression of transcriptional repressor genes such
as Hes1, leading to repression of proneural gene expression and maintenance of neural …

The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore
are critical for the biological effects mediated by thyroid hormone. Over the years, research …

Stem cells reside in specialized niches that regulate their self-renewal and differentiation.
The vasculature is emerging as an important component of stem cell niches. Here, we show …

The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during
embryonic development and adult tissue homeostasis. Here we review the current …