Keeping up with a Quickly Diversifying Pharmaceutical Landscape
A Goyon - ACS Measurement Science Au, 2024 - ACS Publications
Small molecules and antibodies have dominated the pharmaceutical landscape for
decades. However, limitations associated with therapeutic targets deemed" undruggable" …
decades. However, limitations associated with therapeutic targets deemed" undruggable" …
[HTML][HTML] In-silico method development and optimization of on-line comprehensive two-dimensional liquid chromatography via a shortcut model
Comprehensive two-dimensional liquid chromatography (LCxLC) represents a valuable
alternative to conventional single column, or one-dimensional, liquid chromatography (1D …
alternative to conventional single column, or one-dimensional, liquid chromatography (1D …
Introducing Macrocyclic Glycopeptide Columns as Unique Achiral Stationary Phases: Insights from Hydrophobic Subtraction Model and In-Silico Modeling
Background The need for stationary phases with unique selectivity in reversed-phase liquid
chromatography has been of utmost importance to chromatographers for advancing the …
chromatography has been of utmost importance to chromatographers for advancing the …
Improved hydrophobic subtraction model of reversed-phase liquid chromatography selectivity based on a large dataset with a focus on isomer selectivity
SC Rutan, T Kempen, T Dahlseid, Z Kruger… - … of Chromatography A, 2024 - Elsevier
Reversed-phase (RP) liquid chromatography is an important tool for the characterization of
materials and products in the pharmaceutical industry. Method development is still …
materials and products in the pharmaceutical industry. Method development is still …
An improved subtraction model applied in supercritical fluid chromatography to characterise polar stationary phases
D Ge, J Lu, Z Yu, Y Jin, Y Ke, Q Fu, X Liang - Journal of Chromatography A, 2024 - Elsevier
Herein, an improved subtraction model was proposed to characterise the polar stationary
phases in supercritical fluid chromatography (SFC). Fifteen stationary phases were selected …
phases in supercritical fluid chromatography (SFC). Fifteen stationary phases were selected …
[HTML][HTML] A simulation-guided approach to the selection of RPLC columns for platform small molecule separations
Z Liu, JP Foley, JG Shackman, Q Wang… - Journal of Chromatography …, 2024 - Elsevier
Simulations were conducted to evaluate the potential of several hundred reversed-phase
columns to separate small molecules. By calculating the retention factor of compounds in …
columns to separate small molecules. By calculating the retention factor of compounds in …
Tandem-Column High Performance Liquid Chromatography Separation of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
ME Marrazzo, JP Foley - Chromatographia, 2023 - Springer
A tandem-column liquid chromatographic method was developed to separate ten non-
steroidal anti-inflammatory drugs (Aceclofenac, Aspirin, Carprofen, Celecoxib, Diclofenac …
steroidal anti-inflammatory drugs (Aceclofenac, Aspirin, Carprofen, Celecoxib, Diclofenac …