The Soret effect describes diffusive motion that originates from a temperature gradient. It is
observed in mixtures of gases, liquids and even solids. Although there is a formal …

The study of biomolecular interactions is crucial to get more insight into the biological
system. The interactions of protein-protein, protein-nucleic acids, protein-sugars, nucleic …

Immunotherapy has revolutionized cancer treatment, but its efficacy is severely hindered by
the lack of effective predictors. Herein, we developed a homogeneous, low‐volume, efficient …

Protein interactions inside the human body are expected to differ from the situation in vitro.
This is crucial when investigating protein functions or developing new drugs. In this study …

A temperature gradient acts like an external field on colloidal suspensions and drives the
solute particles to the cold or to the warm, depending on interfacial and solvent properties …

Quantification of biomolecular binding reactions in their native environment is crucial for
biology and medicine. However, reliable methods are rare. We have developed a new …

Chemiosmotic coupling is universal: practically all cells harness electrochemical proton
gradients across membranes to drive ATP synthesis, powering biochemistry. Autotrophic …

This Review addresses methods for obtaining sequence information directly from
unamplified genomic length DNA. Our generic starting point is a large piece of DNA that …

For the emergence of early life, the formation of biopolymers such as RNA is essential.
However, the addition of nucleotide monomers to existing oligonucleotides requires …

Non-equilibrium conditions must have been crucial for the assembly of the first informational
polymers of early life, by supporting their formation and continuous enrichment in a long …