Metabolomics is the comprehensive assessment of endogenous metabolites and attempts to
systematically identify and quantify metabolites from a biological sample. Small-molecule …

Metabolomics, an analytical study with high-throughput profiling, helps to understand
interactions within a biological system. Small molecules, called metabolites or metabolomes …

Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early
disease stages, its effects on biological processes or the transition to clinical T2D. To …

Type 2 diabetes (T2D) can be prevented in pre‐diabetic individuals with impaired glucose
tolerance (IGT). Here, we have used a metabolomics approach to identify candidate …

Using a nontargeted metabolomics approach of 447 fasting plasma metabolites, we
searched for novel molecular markers that arise before and after hyperglycemia in a large …

Alzheimer's Disease (AD) currently affects more than 5 million Americans, with numbers
expected to grow dramatically as the population ages. The pathophysiological changes in …

OBJECTIVE Specific lipid molecular changes leading to type 2 diabetes (T2D) are largely
unknown. We assessed lipidome factors associated with future occurrence of T2D in a …

Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their
quantitative determination may be informative about pathogenic conditions. We searched for …

Insulin resistance progressing to type 2 diabetes mellitus (T2DM) is marked by a broad
perturbation of macronutrient intermediary metabolism. Understanding the biochemical …

Background Obesity and type 2 diabetes (T2DM) are associated with increased circulating
free fatty acids and triacylglycerols. However, very little is known about specific molecular …