Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivo

Y Peng, X Yang, Y Zhang - Applied microbiology and biotechnology, 2005 - Springer
Accumulation of fibrin in the blood vessels usually results in thrombosis, leading to
myocardial infarction and other cardiovascular diseases. For thrombolytic therapy, microbial …

Microbial fibrinolytic enzymes as anti-thrombotics: production, characterisation and prodigious biopharmaceutical applications

C Sharma, A Osmolovskiy, R Singh - Pharmaceutics, 2021 - mdpi.com
Cardiac disorders such as acute myocardial infarction, embolism and stroke are primarily
attributed to excessive fibrin accumulation in the blood vessels, usually consequential in …

Biotechnology, Bioengineering and Applications of Bacillus Nattokinase

L Yuan, C Liangqi, T Xiyu, L Jinyao - Biomolecules, 2022 - mdpi.com
Thrombosis has threatened human health in past decades. Bacillus nattokinase is a
potential low-cost thrombolytic drug without side-effects and has been introduced into the …

Fibrinolytic enzymes in Asian traditional fermented foods

Y Mine, AHK Wong, B Jiang - Food Research International, 2005 - Elsevier
Cardiovascular diseases, such as heart attack and stroke, are the leading causes of death in
North America. According to data provided by the World Health Organization in 2000, heart …

Fibrinolytic enzyme from newly isolated marine bacterium Bacillus subtilis ICTF-1: Media optimization, purification and characterization

PM Mahajan, S Nayak, SS Lele - Journal of bioscience and bioengineering, 2012 - Elsevier
Fibrinolytic enzymes are important in treatment of cardiovascular diseases. The present
work reports isolation, screening and identification of marine cultures for production of …

Purification and characterization of nattokinase from Bacillus subtilis natto B-12

C Wang, M Du, D Zheng, F Kong, G Zu… - Journal of agricultural …, 2009 - ACS Publications
Bacillus subtilis natto B-12 was isolated from natto, a traditional fermented soybean food in
Japan. A fibrinolytic enzyme (B-12 nattokinase) was purified from the supernatant of B …

Activity assessment of microbial fibrinolytic enzymes

E Kotb - Applied microbiology and biotechnology, 2013 - Springer
Conversion of fibrinogen to fibrin inside blood vessels results in thrombosis, leading to
myocardial infarction and other cardiovascular diseases. In general, there are four therapy …

Thrombolytic enzymes of microbial origin: a review

D Diwan, Z Usmani, M Sharma, JW Nelson… - International journal of …, 2021 - mdpi.com
Enzyme therapies are attracting significant attention as thrombolytic drugs during the current
scenario owing to their great affinity, specificity, catalytic activity, and stability. Among various …

[图书][B] Nutraceutical proteins and peptides in health and disease

Y Mine, F Shahidi - 2005 - taylorfrancis.com
Reports of the beneficial health effects of some peptides have begun to make their way into
the scientific literature. Peptides can act as immunomodulators, and have been shown to …

Novel fibrinolytic enzyme in fermented shrimp paste, a traditional Asian fermented seasoning

AHK Wong, Y Mine - Journal of Agricultural and Food Chemistry, 2004 - ACS Publications
A novel fibrinolytic enzyme was purified from fermented shrimp paste, a popular seasoning
used in Asian countries. The enzyme is a monomer with an apparent molecular weight of 18 …