Cerebrospinal fluid shunting complications in children

BW Hanak, RH Bonow, CA Harris, SR Browd - Pediatric neurosurgery, 2017 - karger.com
Although cerebrospinal fluid (CSF) shunt placement is the most common procedure
performed by pediatric neurosurgeons, shunts remain among the most failure-prone life …

Cerebrospinal fluid shunt malfunctions: A reflective review

SYY Low, JRW Kestle, ML Walker, WT Seow - Child's Nervous System, 2023 - Springer
Purpose Pediatric hydrocephalus is a common and challenging condition. To date, the
ventriculoperitoneal shunt (VPS) is still the main lifesaving treatment option. Nonetheless, it …

Shunt-dependent hydrocephalus: management style among members of the American Society of Pediatric Neurosurgeons

MR Kraemer, C Sandoval-Garcia, T Bragg… - Journal of …, 2017 - thejns.org
OBJECTIVE The authors conducted a survey to evaluate differences in the understanding
and management of shunt-dependent hydrocephalus among members of the American …

A multicenter retrospective study of heterogeneous tissue aggregates obstructing ventricular catheters explanted from patients with hydrocephalus

P Hariharan, J Sondheimer, A Petroj, J Gluski… - Fluids and Barriers of …, 2021 - Springer
Background Implantation of ventricular catheters (VCs) to drain cerebrospinal fluid (CSF) is
a standard approach to treat hydrocephalus. VCs fail frequently due to tissue obstructing the …

Toward a better understanding of the cellular basis for cerebrospinal fluid shunt obstruction: report on the construction of a bank of explanted hydrocephalus devices

BW Hanak, EF Ross, CA Harris, SR Browd… - Journal of Neurosurgery …, 2016 - thejns.org
OBJECTIVE Shunt obstruction by cells and/or tissue is the most common cause of shunt
failure. Ventricular catheter obstruction alone accounts for more than 50% of shunt failures in …

Reduced cell attachment to poly(2‐hydroxyethyl methacrylate)‐coated ventricular catheters in vitro

BW Hanak, CY Hsieh, W Donaldson… - … Research Part B …, 2018 - Wiley Online Library
The majority of patients with hydrocephalus are dependent on ventriculoperitoneal shunts
for diversion of excess cerebrospinal fluid. Unfortunately, these shunts are failure‐prone and …

An astrocyte derived extracellular matrix coating reduces astrogliosis surrounding chronically implanted microelectrode arrays in rat cortex

RS Oakes, MD Polei, JL Skousen, PA Tresco - Biomaterials, 2018 - Elsevier
Available evidence suggests that the magnitude of the foreign body response (FBR) to
implants placed in cortical brain tissue is affected by the extent of vasculature damage …

Characterization of a multicenter pediatric-hydrocephalus shunt biobank

J Gluski, P Zajciw, P Hariharan, A Morgan… - Fluids and Barriers of …, 2020 - Springer
Background Pediatric hydrocephalus is a devastating and costly disease. The mainstay of
treatment is still surgical shunting of cerebrospinal fluid (CSF). These shunts fail at a high …

Exploration of clinical predictors of the degree of ventricular catheter obstruction: a multicenter retrospective study

P Hariharan, J Gluski, J Sondheimer, A Petroj… - Journal of …, 2023 - thejns.org
OBJECTIVE The aim of this study was to explore how clinical factors, including the number
of lifetime revision surgeries and the duration of implantation, affect the degree of obstruction …

Enhanced wall shear stress prevents obstruction by astrocytes in ventricular catheters

S Lee, N Kwok, J Holsapple… - Journal of the Royal …, 2020 - royalsocietypublishing.org
The treatment of hydrocephalus often involves the placement of a shunt catheter into the
cerebrospinal ventricular space, though such ventricular catheters often fail by tissue …